Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction
Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-bas...
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2011-01-01
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Online Access: | http://dx.doi.org/10.1093/ecam/nep237 |
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doaj-cddb7feaf92e4513a0891e76212dd0292020-11-24T22:40:00ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882011-01-01201110.1093/ecam/nep237915240Cassia auriculata: Aspects of Safety Pharmacology and Drug InteractionAmrutesh S. Puranik0Ganesh Halade1Sandeep Kumar2Ranjan Mogre3Kishori Apte4Ashok D. B. Vaidya5Bhushan Patwardhan6Interdisciplinary School of Health Sciences, University of Pune, Pune 411007, IndiaUniversity of Texas Health Science Center at San Antonio, San Antonio, TX, USANational Center for Cell Sciences, Pune, IndiaApplied Biotech, Vile Parle, Mumbai, IndiaNational Toxicology Center, Pune, IndiaICMR—Advanced Centre of Reverse Pharmacology, MRC-KHS, Vile Parle, Mumbai, IndiaInterdisciplinary School of Health Sciences, University of Pune, Pune 411007, IndiaSafety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-based supercritical extract of Cassia auriculata for 12 weeks. Our studies indicate that both these extracts are pharmacologically safe and did not show any significant adverse reactions at the tested doses. The traditional hydro-alcoholic extract did not show any significant effect on pharmacokinetics; however, the technology-based supercritical extract caused a significant reduction in absorption of metformin. Our results indicate the need to include pharmacokinetic herb-drug interaction studies as evidence for safety especially for technology-based extracts.http://dx.doi.org/10.1093/ecam/nep237 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amrutesh S. Puranik Ganesh Halade Sandeep Kumar Ranjan Mogre Kishori Apte Ashok D. B. Vaidya Bhushan Patwardhan |
spellingShingle |
Amrutesh S. Puranik Ganesh Halade Sandeep Kumar Ranjan Mogre Kishori Apte Ashok D. B. Vaidya Bhushan Patwardhan Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction Evidence-Based Complementary and Alternative Medicine |
author_facet |
Amrutesh S. Puranik Ganesh Halade Sandeep Kumar Ranjan Mogre Kishori Apte Ashok D. B. Vaidya Bhushan Patwardhan |
author_sort |
Amrutesh S. Puranik |
title |
Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction |
title_short |
Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction |
title_full |
Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction |
title_fullStr |
Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction |
title_full_unstemmed |
Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction |
title_sort |
cassia auriculata: aspects of safety pharmacology and drug interaction |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2011-01-01 |
description |
Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-based supercritical extract of Cassia auriculata for 12 weeks. Our studies indicate that both these extracts are pharmacologically safe and did not show any significant adverse reactions at the tested doses. The traditional hydro-alcoholic extract did not show any significant effect on pharmacokinetics; however, the technology-based supercritical extract caused a significant reduction in absorption of metformin. Our results indicate the need to include pharmacokinetic herb-drug interaction studies as evidence for safety especially for technology-based extracts. |
url |
http://dx.doi.org/10.1093/ecam/nep237 |
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