Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair

AIM: Mineral trioxide aggregate (MTA) was associated to Aloe vera to verify the coadjutant action of that medicinal plant in the bone neoformation process in tibia of rats.MATERIAL AND METHOD: 36 male rats (Rattus norvegicus) were used, divided into two groups of 18 rats each. Two circumferential bo...

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Main Authors: Jessyca Leal Moura FÉ, Caroline de Araújo COELHO, Germana Miranda DAMASCENA, Isadora Mello Vilarinho SOARES, Flávio Ribeiro ALVES, Ísidra Manuela Sousa Portela SANTOS, Carmen Milena Rodrigues Siqueira CARVALHO
Format: Article
Language:English
Published: Universidade Estadual Paulista
Series:Revista de Odontologia da UNESP
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-25772014000500299&lng=en&tlng=en
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spelling doaj-cddd73e3079e4fad843f6da1eb98c2e52020-11-25T00:33:48ZengUniversidade Estadual PaulistaRevista de Odontologia da UNESP1807-257743529930410.1590/rou.2014.048S1807-25772014000500299Aloe vera as vehicle to mineral trioxide aggregate: study in bone repairJessyca Leal Moura FÉCaroline de Araújo COELHOGermana Miranda DAMASCENAIsadora Mello Vilarinho SOARESFlávio Ribeiro ALVESÍsidra Manuela Sousa Portela SANTOSCarmen Milena Rodrigues Siqueira CARVALHOAIM: Mineral trioxide aggregate (MTA) was associated to Aloe vera to verify the coadjutant action of that medicinal plant in the bone neoformation process in tibia of rats.MATERIAL AND METHOD: 36 male rats (Rattus norvegicus) were used, divided into two groups of 18 rats each. Two circumferential bone defects with approximately 5 mm in diameter were made on the right tibia of each animal: the upper defect was filled with blood coagulates in both groups to serve as experimental control and the lower defect was filled with MTA and Aloe vera in experimental (group E1) and MTA and distilled water in experimental (group E2). Seven, 15 and 30 days after surgery, six animals from each group were euthanized and the right tibia of each animal was removed for histological analysis.RESULT: Histologically, experimental group E1 presented better results for the two variables, inflammation [at seven days (p=0.045)] and bone formation [at seven days (p=0.018) and 30 days (p=0.034)], compared to the E2 group.CONCLUSION: The association of MTA and Aloe vera showed potential to reduce the effects of the inflammatory cascade and promote bone neoformation making it to a promising proposal for future use in endodontic therapy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-25772014000500299&lng=en&tlng=enBone regenerationphytotherapeutic drugsinflammationhistologyendodontics
collection DOAJ
language English
format Article
sources DOAJ
author Jessyca Leal Moura FÉ
Caroline de Araújo COELHO
Germana Miranda DAMASCENA
Isadora Mello Vilarinho SOARES
Flávio Ribeiro ALVES
Ísidra Manuela Sousa Portela SANTOS
Carmen Milena Rodrigues Siqueira CARVALHO
spellingShingle Jessyca Leal Moura FÉ
Caroline de Araújo COELHO
Germana Miranda DAMASCENA
Isadora Mello Vilarinho SOARES
Flávio Ribeiro ALVES
Ísidra Manuela Sousa Portela SANTOS
Carmen Milena Rodrigues Siqueira CARVALHO
Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair
Revista de Odontologia da UNESP
Bone regeneration
phytotherapeutic drugs
inflammation
histology
endodontics
author_facet Jessyca Leal Moura FÉ
Caroline de Araújo COELHO
Germana Miranda DAMASCENA
Isadora Mello Vilarinho SOARES
Flávio Ribeiro ALVES
Ísidra Manuela Sousa Portela SANTOS
Carmen Milena Rodrigues Siqueira CARVALHO
author_sort Jessyca Leal Moura FÉ
title Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair
title_short Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair
title_full Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair
title_fullStr Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair
title_full_unstemmed Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair
title_sort aloe vera as vehicle to mineral trioxide aggregate: study in bone repair
publisher Universidade Estadual Paulista
series Revista de Odontologia da UNESP
issn 1807-2577
description AIM: Mineral trioxide aggregate (MTA) was associated to Aloe vera to verify the coadjutant action of that medicinal plant in the bone neoformation process in tibia of rats.MATERIAL AND METHOD: 36 male rats (Rattus norvegicus) were used, divided into two groups of 18 rats each. Two circumferential bone defects with approximately 5 mm in diameter were made on the right tibia of each animal: the upper defect was filled with blood coagulates in both groups to serve as experimental control and the lower defect was filled with MTA and Aloe vera in experimental (group E1) and MTA and distilled water in experimental (group E2). Seven, 15 and 30 days after surgery, six animals from each group were euthanized and the right tibia of each animal was removed for histological analysis.RESULT: Histologically, experimental group E1 presented better results for the two variables, inflammation [at seven days (p=0.045)] and bone formation [at seven days (p=0.018) and 30 days (p=0.034)], compared to the E2 group.CONCLUSION: The association of MTA and Aloe vera showed potential to reduce the effects of the inflammatory cascade and promote bone neoformation making it to a promising proposal for future use in endodontic therapy.
topic Bone regeneration
phytotherapeutic drugs
inflammation
histology
endodontics
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-25772014000500299&lng=en&tlng=en
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