Activation-induced deaminase (AID) localizes to the nucleus in brief pulses.
Activation-induced deaminase (AID) converts C to U and 5-methyl-C to T. These mutagenic activities are critical to immunoglobulin (Ig) gene diversification and epigenetic reprogramming, but they must be tightly controlled to prevent compromising cell fitness. AID acts in the nucleus but localizes pr...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-02-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC6411215?pdf=render |