Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex

Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex

The mechanisms underlying the transmission of Tau in astrocytes are unclear. Here, the authors show that the entry of filamentous recombinant human Tau into astrocytes via the integrin αV/ β1 complex stimulates integrin signaling, resulting in activation of NFκB and astrocyte conversion towards a ne...

Full description

Bibliographic Details
Main Authors: Peng Wang, Yihong Ye
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20322-w
id doaj-cdec948c96584b6d935eee48df496727
record_format Article
spelling doaj-cdec948c96584b6d935eee48df4967272021-01-10T12:19:37ZengNature Publishing GroupNature Communications2041-17232021-01-0112111410.1038/s41467-020-20322-wFilamentous recombinant human Tau activates primary astrocytes via an integrin receptor complexPeng Wang0Yihong Ye1Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthThe mechanisms underlying the transmission of Tau in astrocytes are unclear. Here, the authors show that the entry of filamentous recombinant human Tau into astrocytes via the integrin αV/ β1 complex stimulates integrin signaling, resulting in activation of NFκB and astrocyte conversion towards a neurotoxic state.https://doi.org/10.1038/s41467-020-20322-w
collection DOAJ
language English
format Article
sources DOAJ
author Peng Wang
Yihong Ye
spellingShingle Peng Wang
Yihong Ye
Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
Nature Communications
author_facet Peng Wang
Yihong Ye
author_sort Peng Wang
title Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
title_short Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
title_full Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
title_fullStr Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
title_full_unstemmed Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
title_sort filamentous recombinant human tau activates primary astrocytes via an integrin receptor complex
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-01-01
description The mechanisms underlying the transmission of Tau in astrocytes are unclear. Here, the authors show that the entry of filamentous recombinant human Tau into astrocytes via the integrin αV/ β1 complex stimulates integrin signaling, resulting in activation of NFκB and astrocyte conversion towards a neurotoxic state.
url https://doi.org/10.1038/s41467-020-20322-w
work_keys_str_mv AT pengwang filamentousrecombinanthumantauactivatesprimaryastrocytesviaanintegrinreceptorcomplex
AT yihongye filamentousrecombinanthumantauactivatesprimaryastrocytesviaanintegrinreceptorcomplex
_version_ 1724343045483134976

Similar Items