Serological evidence indicates widespread distribution of rickettsioses in Myanmar
Background: Little research has been published on the prevalence of rickettsial infections in Myanmar. This study determined the seroprevalence of immunoglobulin G (IgG) antibodies to rickettsial species in different regions of Myanmar. Methods: Seven hundred leftover blood samples from patients of...
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Elsevier
2021-02-01
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Series: | International Journal of Infectious Diseases |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220325364 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Philip N.D. Elders Myo Maung Maung Swe Aung Pyae Phyo Alistair R.D. McLean Htet Naing Lin Kyaw Soe Wei Yan Aung Htay Ampai Tanganuchitcharnchai Thel K. Hla Ni Ni Tun Thin Thin Nwe Myat Myat Moe Win May Thein Ni Ni Zaw Wai Mon Kyaw Htun Linn Yin Yin Htwe Frank M. Smithuis Stuart D. Blacksell Elizabeth A. Ashley |
spellingShingle |
Philip N.D. Elders Myo Maung Maung Swe Aung Pyae Phyo Alistair R.D. McLean Htet Naing Lin Kyaw Soe Wei Yan Aung Htay Ampai Tanganuchitcharnchai Thel K. Hla Ni Ni Tun Thin Thin Nwe Myat Myat Moe Win May Thein Ni Ni Zaw Wai Mon Kyaw Htun Linn Yin Yin Htwe Frank M. Smithuis Stuart D. Blacksell Elizabeth A. Ashley Serological evidence indicates widespread distribution of rickettsioses in Myanmar International Journal of Infectious Diseases Scrub typhus Murine typhus Spotted fever group Rickettsial infections Seroprevalence Myanmar |
author_facet |
Philip N.D. Elders Myo Maung Maung Swe Aung Pyae Phyo Alistair R.D. McLean Htet Naing Lin Kyaw Soe Wei Yan Aung Htay Ampai Tanganuchitcharnchai Thel K. Hla Ni Ni Tun Thin Thin Nwe Myat Myat Moe Win May Thein Ni Ni Zaw Wai Mon Kyaw Htun Linn Yin Yin Htwe Frank M. Smithuis Stuart D. Blacksell Elizabeth A. Ashley |
author_sort |
Philip N.D. Elders |
title |
Serological evidence indicates widespread distribution of rickettsioses in Myanmar |
title_short |
Serological evidence indicates widespread distribution of rickettsioses in Myanmar |
title_full |
Serological evidence indicates widespread distribution of rickettsioses in Myanmar |
title_fullStr |
Serological evidence indicates widespread distribution of rickettsioses in Myanmar |
title_full_unstemmed |
Serological evidence indicates widespread distribution of rickettsioses in Myanmar |
title_sort |
serological evidence indicates widespread distribution of rickettsioses in myanmar |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 |
publishDate |
2021-02-01 |
description |
Background: Little research has been published on the prevalence of rickettsial infections in Myanmar. This study determined the seroprevalence of immunoglobulin G (IgG) antibodies to rickettsial species in different regions of Myanmar. Methods: Seven hundred leftover blood samples from patients of all ages in primary care clinics and hospitals in seven regions of Myanmar were collected. Samples were screened for scrub typhus group (STG), typhus group (TG) and spotted fever group (SFG) IgG antibodies using enzyme-linked immunosorbent assays (ELISA). Immunofluorescence assays were performed for the same rickettsial groups to confirm seropositivity if ELISA optical density ≥0.5. Results: Overall IgG seroprevalence was 19% [95% confidence interval (CI) 16–22%] for STG, 5% (95% CI 3–7%) for TG and 3% (95% CI: 2–5%) for SFG. The seroprevalence of STG was particularly high in northern and central Myanmar (59% and 19–33%, respectively). Increasing age was associated with higher odds of STG and TG seropositivity [per 10-year increase, adjusted odds ratio estimate 1.68 (p < 0.01) and 1.24 (p = 0.03), respectively]. Conclusion: Rickettsial infections are widespread in Myanmar, with particularly high seroprevalence of STG IgG antibodies in central and northern regions. Healthcare workers should consider rickettsial infections as common causes of fever in Myanmar. |
topic |
Scrub typhus Murine typhus Spotted fever group Rickettsial infections Seroprevalence Myanmar |
url |
http://www.sciencedirect.com/science/article/pii/S1201971220325364 |
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doaj-cdfd78ab52d6426899cc7b064c7d7f352021-02-07T04:22:10ZengElsevierInternational Journal of Infectious Diseases1201-97122021-02-01103494501Serological evidence indicates widespread distribution of rickettsioses in MyanmarPhilip N.D. Elders0Myo Maung Maung Swe1Aung Pyae Phyo2Alistair R.D. McLean3Htet Naing Lin4Kyaw Soe5Wei Yan Aung Htay6Ampai Tanganuchitcharnchai7Thel K. Hla8Ni Ni Tun9Thin Thin Nwe10Myat Myat Moe11Win May Thein12Ni Ni Zaw13Wai Mon Kyaw14Htun Linn15Yin Yin Htwe16Frank M. Smithuis17Stuart D. Blacksell18Elizabeth A. Ashley19Myanmar Oxford Clinical Research Unit, Yangon, MyanmarMyanmar Oxford Clinical Research Unit, Yangon, MyanmarMyanmar Oxford Clinical Research Unit, Yangon, MyanmarMyanmar Oxford Clinical Research Unit, Yangon, Myanmar; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United KingdomMyanmar Oxford Clinical Research Unit, Yangon, MyanmarMyanmar Oxford Clinical Research Unit, Yangon, MyanmarMyanmar Oxford Clinical Research Unit, Yangon, MyanmarMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, ThailandMyanmar Oxford Clinical Research Unit, Yangon, Myanmar; Medical Action Myanmar, Yangon, MyanmarMedical Action Myanmar, Yangon, MyanmarMagway General Hospital and University of Medicine, Magway, Myanmar; University of Medicine 2, Yangon, MyanmarMagway General Hospital and University of Medicine, Magway, MyanmarMandalay General Hospital and University of Medicine, Mandalay, MyanmarMandalay General Hospital and University of Medicine, Mandalay, MyanmarMonywa General Hospital, Monywa, MyanmarMonywa General Hospital, Monywa, MyanmarNational Health Laboratory, Yangon, MyanmarMyanmar Oxford Clinical Research Unit, Yangon, Myanmar; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Medical Action Myanmar, Yangon, MyanmarCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, ThailandMyanmar Oxford Clinical Research Unit, Yangon, Myanmar; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao Democratic People’s Republic; Corresponding author at: Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Quai Fa Ngum, Vientiane, Lao Democratic People’s Republic.Background: Little research has been published on the prevalence of rickettsial infections in Myanmar. This study determined the seroprevalence of immunoglobulin G (IgG) antibodies to rickettsial species in different regions of Myanmar. Methods: Seven hundred leftover blood samples from patients of all ages in primary care clinics and hospitals in seven regions of Myanmar were collected. Samples were screened for scrub typhus group (STG), typhus group (TG) and spotted fever group (SFG) IgG antibodies using enzyme-linked immunosorbent assays (ELISA). Immunofluorescence assays were performed for the same rickettsial groups to confirm seropositivity if ELISA optical density ≥0.5. Results: Overall IgG seroprevalence was 19% [95% confidence interval (CI) 16–22%] for STG, 5% (95% CI 3–7%) for TG and 3% (95% CI: 2–5%) for SFG. The seroprevalence of STG was particularly high in northern and central Myanmar (59% and 19–33%, respectively). Increasing age was associated with higher odds of STG and TG seropositivity [per 10-year increase, adjusted odds ratio estimate 1.68 (p < 0.01) and 1.24 (p = 0.03), respectively]. Conclusion: Rickettsial infections are widespread in Myanmar, with particularly high seroprevalence of STG IgG antibodies in central and northern regions. Healthcare workers should consider rickettsial infections as common causes of fever in Myanmar.http://www.sciencedirect.com/science/article/pii/S1201971220325364Scrub typhusMurine typhusSpotted fever groupRickettsial infectionsSeroprevalenceMyanmar |