Preneoplastic lesions of the lung
<p>Abstract</p> <p>Lung cancer is the leading cause of cancer deaths worldwide. If we can define and detect preneoplastic lesions, we might have a chance of improving survival. The World Health Organization has defined three preneoplastic lesions of the bronchial epithelium: squamo...
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2002-04-01
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| Series: | Respiratory Research |
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| Online Access: | http://dx.doi.org/10.1186/rr170 |
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doaj-ce0810f0881a4cc2816e6c152707e2a32020-11-25T01:58:20ZengBMCRespiratory Research1465-99212002-04-01312010.1186/rr170Preneoplastic lesions of the lungYee HermanGreenberg Alissa KRom William N<p>Abstract</p> <p>Lung cancer is the leading cause of cancer deaths worldwide. If we can define and detect preneoplastic lesions, we might have a chance of improving survival. The World Health Organization has defined three preneoplastic lesions of the bronchial epithelium: squamous dysplasia/carcinoma <it>in situ</it>; atypical adenomatous hyperplasia; and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. These lesions are believed to progress to squamous cell carcinoma, adenocarcinoma and carcinoid tumors, respectively. In this review we summarize the data supporting the preneoplastic nature of these lesions, and delve into some of the genetic changes found in atypical adenomatous hyperplasia and squamous dysplasia/carcinoma <it>in situ</it>.</p> http://dx.doi.org/10.1186/rr170bronchial epitheliumcarcinogenesislung cancerpreneoplasia |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yee Herman Greenberg Alissa K Rom William N |
| spellingShingle |
Yee Herman Greenberg Alissa K Rom William N Preneoplastic lesions of the lung Respiratory Research bronchial epithelium carcinogenesis lung cancer preneoplasia |
| author_facet |
Yee Herman Greenberg Alissa K Rom William N |
| author_sort |
Yee Herman |
| title |
Preneoplastic lesions of the lung |
| title_short |
Preneoplastic lesions of the lung |
| title_full |
Preneoplastic lesions of the lung |
| title_fullStr |
Preneoplastic lesions of the lung |
| title_full_unstemmed |
Preneoplastic lesions of the lung |
| title_sort |
preneoplastic lesions of the lung |
| publisher |
BMC |
| series |
Respiratory Research |
| issn |
1465-9921 |
| publishDate |
2002-04-01 |
| description |
<p>Abstract</p> <p>Lung cancer is the leading cause of cancer deaths worldwide. If we can define and detect preneoplastic lesions, we might have a chance of improving survival. The World Health Organization has defined three preneoplastic lesions of the bronchial epithelium: squamous dysplasia/carcinoma <it>in situ</it>; atypical adenomatous hyperplasia; and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. These lesions are believed to progress to squamous cell carcinoma, adenocarcinoma and carcinoid tumors, respectively. In this review we summarize the data supporting the preneoplastic nature of these lesions, and delve into some of the genetic changes found in atypical adenomatous hyperplasia and squamous dysplasia/carcinoma <it>in situ</it>.</p> |
| topic |
bronchial epithelium carcinogenesis lung cancer preneoplasia |
| url |
http://dx.doi.org/10.1186/rr170 |
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AT yeeherman preneoplasticlesionsofthelung AT greenbergalissak preneoplasticlesionsofthelung AT romwilliamn preneoplasticlesionsofthelung |
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