Effect of p-chlorophenoxyisobutyrate (CPIB) fed to rats on hepatic biosynthesis and catabolism of ubiquinone

The effect of p-chlorophenoxyisobutyrate (CPIB) feeding on cholesterol and ubiquinone metabolism in rats was investigated. The results obtained from acetate-l-14C and mevalonate-2-14C incorporation studies both in vivo and in vitro confirm the results of other workers that CPIB feeding caused a meta...

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Main Authors:	M.R. Lakshmanan, W.E.J. Phillips, R.L. Brien
Format:	Article
Language:	English
Published:	Elsevier 1968-05-01
Series:	Journal of Lipid Research
Subjects:	CPIB cholesterol ubiquinone hydrocarbon biosynthesis turnover
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520431049

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spelling	doaj-ce0de986d6ec422db18de67a64f27da52021-04-24T05:55:26ZengElsevierJournal of Lipid Research0022-22751968-05-0193353356Effect of p-chlorophenoxyisobutyrate (CPIB) fed to rats on hepatic biosynthesis and catabolism of ubiquinoneM.R. Lakshmanan0W.E.J. Phillips1R.L. Brien2Research Laboratories, Food and Drug Directorate, Department of National Health and Welfare, Ottawa, CanadaResearch Laboratories, Food and Drug Directorate, Department of National Health and Welfare, Ottawa, CanadaResearch Laboratories, Food and Drug Directorate, Department of National Health and Welfare, Ottawa, CanadaThe effect of p-chlorophenoxyisobutyrate (CPIB) feeding on cholesterol and ubiquinone metabolism in rats was investigated. The results obtained from acetate-l-14C and mevalonate-2-14C incorporation studies both in vivo and in vitro confirm the results of other workers that CPIB feeding caused a metabolic block in the conversion of acetate to mevalonate, thereby inhibiting over-all steroidogenesis. Liver ubiquinone synthesis was inhibited in CPIB-fed rats, but a block in the catabolism of the ubiquinone resulted in accumulation of ubiquinone in CPIB-fed animals.http://www.sciencedirect.com/science/article/pii/S0022227520431049CPIBcholesterolubiquinonehydrocarbonbiosynthesisturnover
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	M.R. Lakshmanan W.E.J. Phillips R.L. Brien
spellingShingle	M.R. Lakshmanan W.E.J. Phillips R.L. Brien Effect of p-chlorophenoxyisobutyrate (CPIB) fed to rats on hepatic biosynthesis and catabolism of ubiquinone Journal of Lipid Research CPIB cholesterol ubiquinone hydrocarbon biosynthesis turnover
author_facet	M.R. Lakshmanan W.E.J. Phillips R.L. Brien
author_sort	M.R. Lakshmanan
title	Effect of p-chlorophenoxyisobutyrate (CPIB) fed to rats on hepatic biosynthesis and catabolism of ubiquinone
title_short	Effect of p-chlorophenoxyisobutyrate (CPIB) fed to rats on hepatic biosynthesis and catabolism of ubiquinone
title_full	Effect of p-chlorophenoxyisobutyrate (CPIB) fed to rats on hepatic biosynthesis and catabolism of ubiquinone
title_fullStr	Effect of p-chlorophenoxyisobutyrate (CPIB) fed to rats on hepatic biosynthesis and catabolism of ubiquinone
title_full_unstemmed	Effect of p-chlorophenoxyisobutyrate (CPIB) fed to rats on hepatic biosynthesis and catabolism of ubiquinone
title_sort	effect of p-chlorophenoxyisobutyrate (cpib) fed to rats on hepatic biosynthesis and catabolism of ubiquinone
publisher	Elsevier
series	Journal of Lipid Research
issn	0022-2275
publishDate	1968-05-01
description	The effect of p-chlorophenoxyisobutyrate (CPIB) feeding on cholesterol and ubiquinone metabolism in rats was investigated. The results obtained from acetate-l-14C and mevalonate-2-14C incorporation studies both in vivo and in vitro confirm the results of other workers that CPIB feeding caused a metabolic block in the conversion of acetate to mevalonate, thereby inhibiting over-all steroidogenesis. Liver ubiquinone synthesis was inhibited in CPIB-fed rats, but a block in the catabolism of the ubiquinone resulted in accumulation of ubiquinone in CPIB-fed animals.
topic	CPIB cholesterol ubiquinone hydrocarbon biosynthesis turnover
url	http://www.sciencedirect.com/science/article/pii/S0022227520431049
work_keys_str_mv	AT mrlakshmanan effectofpchlorophenoxyisobutyratecpibfedtoratsonhepaticbiosynthesisandcatabolismofubiquinone AT wejphillips effectofpchlorophenoxyisobutyratecpibfedtoratsonhepaticbiosynthesisandcatabolismofubiquinone AT rlbrien effectofpchlorophenoxyisobutyratecpibfedtoratsonhepaticbiosynthesisandcatabolismofubiquinone
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Effect of p-chlorophenoxyisobutyrate (CPIB) fed to rats on hepatic biosynthesis and catabolism of ubiquinone

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