Multiple functional risk variants in a SMAD7 enhancer implicate a colorectal cancer risk haplotype.

Multiple functional risk variants in a SMAD7 enhancer implicate a colorectal cancer risk haplotype.

Genome-wide association studies (GWAS) of colorectal cancer (CRC) have led to the identification of a number of common variants associated with modest risk. Several risk variants map within the vicinity of TGFβ/BMP signaling pathway genes, including rs4939827 within an intron of SMAD7 at 18q21.1. A...

Full description

Bibliographic Details
Main Authors: Barbara K Fortini, Stephanie Tring, Sarah J Plummer, Christopher K Edlund, Victor Moreno, Robert S Bresalier, Elizabeth L Barry, Timothy R Church, Jane C Figueiredo, Graham Casey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4223076?pdf=render

Similar Items

Similar Items