Involvement of Gut Microbiota in Schizophrenia and Treatment Resistance to Antipsychotics
The gut microbiota is constituted by more than 40,000 bacterial species involved in key processes including high order brain functions. Altered composition of gut microbiota has been implicated in psychiatric disorders and in modulating the efficacy and safety of psychotropic medications. In this wo...
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doaj-ce132ba8ce0047f6bf1d9829937c1c452021-08-26T13:32:34ZengMDPI AGBiomedicines2227-90592021-07-01987587510.3390/biomedicines9080875Involvement of Gut Microbiota in Schizophrenia and Treatment Resistance to AntipsychoticsMirko Manchia0Andrea Fontana1Concetta Panebianco2Pasquale Paribello3Carlo Arzedi4Eleonora Cossu5Mario Garzilli6Maria Antonietta Montis7Andrea Mura8Claudia Pisanu9Donatella Congiu10Massimiliano Copetti11Federica Pinna12Valerio Pazienza13Alessio Squassina14Bernardo Carpiniello15Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09127 Cagliari, ItalyUnit of Biostatistics, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, 71013 San Giovanni Rotondo, ItalyDivision of Gastroenterology, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, 71013 San Giovanni Rotondo, ItalyUnit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09127 Cagliari, ItalyUnit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09127 Cagliari, ItalyUnit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09127 Cagliari, ItalyUnit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09127 Cagliari, ItalyUnit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09127 Cagliari, ItalyUnit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09127 Cagliari, ItalyUnit of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Cagliari, ItalyUnit of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Cagliari, ItalyUnit of Biostatistics, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, 71013 San Giovanni Rotondo, ItalyUnit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09127 Cagliari, ItalyDivision of Gastroenterology, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, 71013 San Giovanni Rotondo, ItalyUnit of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Cagliari, ItalyUnit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09127 Cagliari, ItalyThe gut microbiota is constituted by more than 40,000 bacterial species involved in key processes including high order brain functions. Altered composition of gut microbiota has been implicated in psychiatric disorders and in modulating the efficacy and safety of psychotropic medications. In this work we characterized the composition of the gut microbiota in 38 patients with schizophrenia (SCZ) and 20 healthy controls (HC), and tested if SCZ patients with different response to antipsychotics (18 patients with treatment resistant schizophrenia (TRS), and 20 responders (R)) had specific patterns of gut microbiota composition associated with different response to antipsychotics. Moreover, we also tested if patients treated with typical antipsychotics (n = 20) presented significant differences when compared to patients treated with atypical antipsychotics (n = 31). Our findings showed the presence of distinct composition of gut microbiota in SCZ versus HC, with several bacteria at the different taxonomic levels only present in either one group or the other. Similar findings were observed also depending on treatment response and exposure to diverse classes of antipsychotics. Our results suggest that composition of gut microbiota could constitute a biosignatures of SCZ and TRS.https://www.mdpi.com/2227-9059/9/8/875severe mental disorderspsychosispharmacogeneticspharmacogenomicsmicrobiomediet |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mirko Manchia Andrea Fontana Concetta Panebianco Pasquale Paribello Carlo Arzedi Eleonora Cossu Mario Garzilli Maria Antonietta Montis Andrea Mura Claudia Pisanu Donatella Congiu Massimiliano Copetti Federica Pinna Valerio Pazienza Alessio Squassina Bernardo Carpiniello |
spellingShingle |
Mirko Manchia Andrea Fontana Concetta Panebianco Pasquale Paribello Carlo Arzedi Eleonora Cossu Mario Garzilli Maria Antonietta Montis Andrea Mura Claudia Pisanu Donatella Congiu Massimiliano Copetti Federica Pinna Valerio Pazienza Alessio Squassina Bernardo Carpiniello Involvement of Gut Microbiota in Schizophrenia and Treatment Resistance to Antipsychotics Biomedicines severe mental disorders psychosis pharmacogenetics pharmacogenomics microbiome diet |
author_facet |
Mirko Manchia Andrea Fontana Concetta Panebianco Pasquale Paribello Carlo Arzedi Eleonora Cossu Mario Garzilli Maria Antonietta Montis Andrea Mura Claudia Pisanu Donatella Congiu Massimiliano Copetti Federica Pinna Valerio Pazienza Alessio Squassina Bernardo Carpiniello |
author_sort |
Mirko Manchia |
title |
Involvement of Gut Microbiota in Schizophrenia and Treatment Resistance to Antipsychotics |
title_short |
Involvement of Gut Microbiota in Schizophrenia and Treatment Resistance to Antipsychotics |
title_full |
Involvement of Gut Microbiota in Schizophrenia and Treatment Resistance to Antipsychotics |
title_fullStr |
Involvement of Gut Microbiota in Schizophrenia and Treatment Resistance to Antipsychotics |
title_full_unstemmed |
Involvement of Gut Microbiota in Schizophrenia and Treatment Resistance to Antipsychotics |
title_sort |
involvement of gut microbiota in schizophrenia and treatment resistance to antipsychotics |
publisher |
MDPI AG |
series |
Biomedicines |
issn |
2227-9059 |
publishDate |
2021-07-01 |
description |
The gut microbiota is constituted by more than 40,000 bacterial species involved in key processes including high order brain functions. Altered composition of gut microbiota has been implicated in psychiatric disorders and in modulating the efficacy and safety of psychotropic medications. In this work we characterized the composition of the gut microbiota in 38 patients with schizophrenia (SCZ) and 20 healthy controls (HC), and tested if SCZ patients with different response to antipsychotics (18 patients with treatment resistant schizophrenia (TRS), and 20 responders (R)) had specific patterns of gut microbiota composition associated with different response to antipsychotics. Moreover, we also tested if patients treated with typical antipsychotics (n = 20) presented significant differences when compared to patients treated with atypical antipsychotics (n = 31). Our findings showed the presence of distinct composition of gut microbiota in SCZ versus HC, with several bacteria at the different taxonomic levels only present in either one group or the other. Similar findings were observed also depending on treatment response and exposure to diverse classes of antipsychotics. Our results suggest that composition of gut microbiota could constitute a biosignatures of SCZ and TRS. |
topic |
severe mental disorders psychosis pharmacogenetics pharmacogenomics microbiome diet |
url |
https://www.mdpi.com/2227-9059/9/8/875 |
work_keys_str_mv |
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