Lack of Association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid Arthritis
Introduction. Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. Recent studies have identified the ABO rs579459, PPAP2B rs17114036, and ADAMTS7 rs3825807 polymorphisms as genetic variants associated with coronary...
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Language: | English |
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Hindawi Limited
2014-01-01
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Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/2014/756279 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Raquel López-Mejías Fernanda Genre Mercedes García-Bermúdez Begoña Ubilla Santos Castañeda Javier Llorca Carlos González-Juanatey Alfonso Corrales José A. Miranda-Filloy Trinitario Pina Carmen Gómez-Vaquero Luis Rodríguez-Rodríguez Benjamín Fernández-Gutiérrez Alejandro Balsa Dora Pascual-Salcedo Francisco J. López-Longo Patricia Carreira Ricardo Blanco Javier Martín Miguel A. González-Gay |
spellingShingle |
Raquel López-Mejías Fernanda Genre Mercedes García-Bermúdez Begoña Ubilla Santos Castañeda Javier Llorca Carlos González-Juanatey Alfonso Corrales José A. Miranda-Filloy Trinitario Pina Carmen Gómez-Vaquero Luis Rodríguez-Rodríguez Benjamín Fernández-Gutiérrez Alejandro Balsa Dora Pascual-Salcedo Francisco J. López-Longo Patricia Carreira Ricardo Blanco Javier Martín Miguel A. González-Gay Lack of Association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid Arthritis Mediators of Inflammation |
author_facet |
Raquel López-Mejías Fernanda Genre Mercedes García-Bermúdez Begoña Ubilla Santos Castañeda Javier Llorca Carlos González-Juanatey Alfonso Corrales José A. Miranda-Filloy Trinitario Pina Carmen Gómez-Vaquero Luis Rodríguez-Rodríguez Benjamín Fernández-Gutiérrez Alejandro Balsa Dora Pascual-Salcedo Francisco J. López-Longo Patricia Carreira Ricardo Blanco Javier Martín Miguel A. González-Gay |
author_sort |
Raquel López-Mejías |
title |
Lack of Association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid Arthritis |
title_short |
Lack of Association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid Arthritis |
title_full |
Lack of Association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid Arthritis |
title_fullStr |
Lack of Association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid Arthritis |
title_full_unstemmed |
Lack of Association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid Arthritis |
title_sort |
lack of association between abo, ppap2b, adamst7, pik3cg, and ednra and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritis |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
2014-01-01 |
description |
Introduction. Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. Recent studies have identified the ABO rs579459, PPAP2B rs17114036, and ADAMTS7 rs3825807 polymorphisms as genetic variants associated with coronary artery disease and the PIK3CG rs17398575 and EDNRA rs1878406 polymorphisms as the most significant signals related to the presence of carotid plaque in nonrheumatic Caucasian individuals. Accordingly, we evaluated the potential relationship between these 5 polymorphisms and subclinical atherosclerosis (assessed by carotid intima-media thickness (cIMT) and presence/absence of carotid plaques) and CV disease in RA. Material and Methods. 2140 Spanish RA patients were genotyped for the 5 polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 620 of these patients by carotid ultrasonography technology. Results. No statistically significant differences were found when each polymorphism was assessed according to cIMT values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV disease after adjusting for potential confounders. Conclusion. Our results do not confirm association between ABO rs579459, PPAP2B rs17114036, ADAMTS7 rs3825807, PIK3CG rs17398575, and EDNRA rs1878406 and subclinical atherosclerosis and CV disease in RA. |
url |
http://dx.doi.org/10.1155/2014/756279 |
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doaj-ce1c8d6fe54c4194800708358d30af472020-11-24T21:02:24ZengHindawi LimitedMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/756279756279Lack of Association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid ArthritisRaquel López-Mejías0Fernanda Genre1Mercedes García-Bermúdez2Begoña Ubilla3Santos Castañeda4Javier Llorca5Carlos González-Juanatey6Alfonso Corrales7José A. Miranda-Filloy8Trinitario Pina9Carmen Gómez-Vaquero10Luis Rodríguez-Rodríguez11Benjamín Fernández-Gutiérrez12Alejandro Balsa13Dora Pascual-Salcedo14Francisco J. López-Longo15Patricia Carreira16Ricardo Blanco17Javier Martín18Miguel A. González-Gay19Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Avenida Cardenal Herrera Oria s/n, 39011 Santander, SpainEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Avenida Cardenal Herrera Oria s/n, 39011 Santander, SpainInstitute of Parasitología and Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s/n, Armilla, 18100 Granada, SpainEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Avenida Cardenal Herrera Oria s/n, 39011 Santander, SpainDepartment of Rheumatology, Hospital Universitario la Princesa, IIS-Princesa, Diego de León 62, 28006 Madrid, SpainDepartment of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Avenida Cardenal Herrera Oria s/n, 39011 Santander, SpainCardiology Division, Hospital Universitario Lucus Augusti, Doctor Ochoa s/n, 27004 Lugo, SpainEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Avenida Cardenal Herrera Oria s/n, 39011 Santander, SpainDepartment of Rheumatology, Hospital Universitario Lucus Augusti, Doctor Ochoa s/n, 27004 Lugo, SpainEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Avenida Cardenal Herrera Oria s/n, 39011 Santander, SpainDepartment of Rheumatology, Hospital Universitario Bellvitge, Feixa Llarga s/n, 08907 Barcelona, SpainDepartment of Rheumatology, Hospital Clínico San Carlos, Profesor Martín Lagos s/n, 28040 Madrid, SpainDepartment of Rheumatology, Hospital Clínico San Carlos, Profesor Martín Lagos s/n, 28040 Madrid, SpainDepartment of Rheumatology, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, SpainDepartment of Rheumatology, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, SpainDepartment of Rheumatology, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo 46, 28007 Madrid, SpainDepartment of Rheumatology, Hospital Universitario 12 de Octubre, Avenida de Córdoba s/n, 28041 Madrid, SpainEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Avenida Cardenal Herrera Oria s/n, 39011 Santander, SpainInstitute of Parasitología and Biomedicina López-Neyra, IPBLN-CSIC, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s/n, Armilla, 18100 Granada, SpainEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Avenida Cardenal Herrera Oria s/n, 39011 Santander, SpainIntroduction. Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. Recent studies have identified the ABO rs579459, PPAP2B rs17114036, and ADAMTS7 rs3825807 polymorphisms as genetic variants associated with coronary artery disease and the PIK3CG rs17398575 and EDNRA rs1878406 polymorphisms as the most significant signals related to the presence of carotid plaque in nonrheumatic Caucasian individuals. Accordingly, we evaluated the potential relationship between these 5 polymorphisms and subclinical atherosclerosis (assessed by carotid intima-media thickness (cIMT) and presence/absence of carotid plaques) and CV disease in RA. Material and Methods. 2140 Spanish RA patients were genotyped for the 5 polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 620 of these patients by carotid ultrasonography technology. Results. No statistically significant differences were found when each polymorphism was assessed according to cIMT values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV disease after adjusting for potential confounders. Conclusion. Our results do not confirm association between ABO rs579459, PPAP2B rs17114036, ADAMTS7 rs3825807, PIK3CG rs17398575, and EDNRA rs1878406 and subclinical atherosclerosis and CV disease in RA.http://dx.doi.org/10.1155/2014/756279 |