AIRE deficiency, from preclinical models to human APECED disease

AIRE deficiency, from preclinical models to human APECED disease

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a rare life-threatening autoimmune disease that attacks multiple organs and has its onset in childhood. It is an inherited condition caused by a variety of mutations in the autoimmune regulator (AIRE) gene that encodes a prot...

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Bibliographic Details
Main Authors: Marine Besnard, Francine Padonou, Nathan Provin, Matthieu Giraud, Carole Guillonneau
Format: Article
Language:English
Published: The Company of Biologists 2021-02-01
Series:Disease Models & Mechanisms
Subjects:
aire
mtec
apeced
aps-1
organoid
knockout model
Online Access:http://dmm.biologists.org/content/14/2/dmm046359

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