Gamma-Chain Receptor Cytokines & PD-1 Manipulation to Restore HCV-Specific CD8<sup>+</sup> T Cell Response during Chronic Hepatitis C

Gamma-Chain Receptor Cytokines & PD-1 Manipulation to Restore HCV-Specific CD8<sup>+</sup> T Cell Response during Chronic Hepatitis C

Hepatitis C virus (HCV)-specific CD8<sup>+</sup> T cell response is essential in natural HCV infection control, but it becomes exhausted during persistent infection. Nowadays, chronic HCV infection can be resolved by direct acting anti-viral treatment, but there are still some non-respon...

Full description

Bibliographic Details
Main Authors:	Julia Peña-Asensio, Henar Calvo, Miguel Torralba, Joaquín Miquel, Eduardo Sanz-de-Villalobos, Juan-Ramón Larrubia
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	Cells
Subjects:	Hepatitis C virus CD8<sup>+</sup> T cell response exhaustion immune checkpoints γ-chain cytokines PD-1
Online Access:	https://www.mdpi.com/2073-4409/10/3/538

Similar Items

CD8<sup>+</sup> T Cell Responses during HCV Infection and HCC
by: Maike Hofmann, et al.
Published: (2021-03-01)

PD-L1 Overexpression, SWI/SNF Complex Deregulation, and Profound Transcriptomic Changes Characterize Cancer-Dependent Exhaustion of Persistently Activated CD4<sup>+</sup> T Cells
by: Iga Jancewicz, et al.
Published: (2021-08-01)

In-vitro inhibition of IFNγ<sup>+</sup> iTreg mediated by monoclonal antibodies against cell surface determinants essential for iTreg function
by: Daniel Volker, et al.
Published: (2012-08-01)

Role of Intracellular Na<sup>+</sup> in the Regulation of [Ca<sup>2+</sup>]<sub>i</sub> in the Rat Suprachiasmatic Nucleus Neurons
by: Ruo-Ciao Cheng, et al.
Published: (2019-09-01)

Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients: Cellactose<sup>®</sup> 80, CombiLac<sup>®</sup>, MicroceLac<sup>®</sup> 100, and StarLac<sup>®</sup>
by: Martin Dominik, et al.
Published: (2021-09-01)

Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8<sup>+</sup> T Cell Response in Hepatocellular Carcinoma
by: Julia Peña-Asensio, et al.
Published: (2021-04-01)

Comparative study of serum Na<sup>+ </sup>and K<sup>+ </sup> levels in senile cataract patients and normal individuals
Published: (2004-08-01)

Mitochondrial DNA tRNA<sup>Leu</sup> and tRNA<sup>Ser</sup> polymorphism in different pig breeds
by: M. A. Kolosova, et al.
Published: (2018-10-01)

Photoproduction of K<sup>*+</sup>¿¿/¿¿<sup>0</sup> and K<sup>0</sup>¿¿<sup>+</sup> from the Proton Using CLAS at Jefferson Lab
by: Tang, Wei
Published: (2012)

Spinach Plants Favor the Absorption of K<sup>+</sup> over Na<sup>+</sup> Regardless of Salinity, and May Benefit from Na<sup>+</sup> When K<sup>+</sup> is Deficient in the Soil
by: Jorge F. S. Ferreira, et al.
Published: (2020-04-01)

CD4<sup>+</sup> T-Cell Plasticity in Non-Infectious Retinal Inflammatory Disease
by: Yi-Hsing Chen, et al.
Published: (2021-09-01)

Preparation and Preliminary Evaluation of Neurotensin Radiolabelled with <sup>68</sup>Ga and <sup>177</sup>Lu as Potential Theranostic Agent for Colon Cancer
by: Radu Anton Leonte, et al.
Published: (2021-04-01)

<sup>7</sup>Be, <sup>210</sup>Pb<sub>atm</sub> and <sup>137</sup>Cs in Snow Deposits in the Arctic Part of Western Siberia (Yamal-Nenets Autonomous District)
by: Kseniya Mezina, et al.
Published: (2020-08-01)

Heat-Affected-Zone Liquation Cracking in Welded Cast Haynes<sup>®</sup> 282<sup>®</sup>
by: Sukhdeep Singh, et al.
Published: (2019-12-01)

CD3<sup>+</sup>, CD8<sup>+</sup>, CD4<sup>+</sup> and FOXP3<sup>+</sup> T Cells in the Immune Microenvironment of Small Bowel Neuroendocrine Tumors
by: Niko Hiltunen, et al.
Published: (2021-06-01)

New Insights into the Structure-Function Relationship of the Endosomal-Type Na<sup>+</sup>, K<sup>+</sup>/H<sup>+</sup> Antiporter NHX6 from Mulberry (<i>Morus notabilis</i>)
by: Boning Cao, et al.
Published: (2020-01-01)

Compatible Stability and Aerosol Characteristics of Atrovent<sup>®</sup> (Ipratropium Bromide) Mixed with Salbutamol Sulfate, Terbutaline Sulfate, Budesonide, and Acetylcysteine
by: Yiting Chen, et al.
Published: (2020-08-01)

Na<sup>+</sup>/K<sup>+</sup> Hybrid Battery Based on a Sulfurized Polyacrylonitrile Cathode
by: Jin Lou, et al.
Published: (2019-03-01)

Interaction of (+)-Strebloside and Its Derivatives with Na<sup>+</sup>/K<sup>+</sup>-ATPase and Other Targets
by: Yulin Ren, et al.
Published: (2021-09-01)

Labelling via [Al<sup>18</sup>F]<sup>2+</sup> Using Precomplexed Al-NODA Moieties
by: Daniel Kang, et al.
Published: (2021-08-01)

Midazolam’s Effects on Delayed-Rectifier K<sup>+</sup> Current and Intermediate-Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channel in Jurkat T-lymphocytes
by: Ning-Ping Foo, et al.
Published: (2021-07-01)

The inflow of <sup>234</sup>U and <sup>238</sup>U from the River Odra drainage basin to the Baltic Sea
by: Bogdan Skwarzec, et al.
Published: (2010-12-01)

Tabotamp<sup>®</sup>, Respectively, Surgicel<sup>®</sup>, Increases the Cell Death of Neuronal and Glial Cells In Vitro
by: Sandra Leisz, et al.
Published: (2020-05-01)

CD8<sup>+</sup> T Cells in Atherosclerosis
by: Sarah Schäfer, et al.
Published: (2021-12-01)

Genome-Wide Identification of Na<sup>+</sup>/H<sup>+</sup> Antiporter (NHX) Genes in Sugar Beet (<i>Beta vulgaris</i> L.) and Their Regulated Expression under Salt Stress
by: Guo-Qiang Wu, et al.
Published: (2019-05-01)

Therapeutic Potential of <sup>47</sup>Sc in Comparison to <sup>177</sup>Lu and <sup>90</sup>Y: Preclinical Investigations
by: Klaudia Siwowska, et al.
Published: (2019-08-01)

<it>Wld<sup>S </sup></it>but not Nmnat1 protects dopaminergic neurites from MPP<sup>+ </sup>neurotoxicity
by: Antenor-Dorsey Jo Ann V, et al.
Published: (2012-02-01)

Quantitative Dynamic <sup>18</sup>F-FDG PET/CT in Survival Prediction of Metastatic Melanoma under PD-1 Inhibitors
by: Christos Sachpekidis, et al.
Published: (2021-03-01)

Nitrogen Cycle Dynamics Revealed Through δ<sup>18</sup>O-NO<sub>3</sub><sup>−</sup> Analysis in California Groundwater
by: Nate Veale, et al.
Published: (2019-02-01)

Semipermeable Mixed Phospholipid-Fatty Acid Membranes Exhibit K<sup>+</sup>/Na<sup>+</sup> Selectivity in the Absence of Proteins
by: Xianfeng Zhou, et al.
Published: (2020-04-01)

<em>H</em>-Umbilical Lagrangian Submanifolds of the Nearly Kähler S<sup>3</sup> × S<sup>3</sup>
by: Miroslava Antić, et al.
Published: (2020-08-01)

Prognostic and Therapeutic Implications of Immune Classification by CD8<sup>+</sup> Tumor-Infiltrating Lymphocytes and PD-L1 Expression in Sinonasal Squamous Cell Carcinoma
by: Rocío García-Marín, et al.
Published: (2021-06-01)

In Vitro Cell Sensitivity to Palytoxin Correlates with High Gene Expression of the Na<sup>+</sup>/K<sup>+</sup>-ATPase β2 Subunit Isoform
by: Marco Pelin, et al.
Published: (2020-08-01)

Effect of Steamed Potato Bread Intake on Glucose, Lipids, and Urinary Na<sup>+</sup> and K<sup>+</sup>: A Randomized Controlled Trial with Adolescents
by: Haiquan Xu, et al.
Published: (2020-03-01)

Structural Insights into the Interactions of Digoxin and Na<sup>+</sup>/K<sup>+</sup>-ATPase and Other Targets for the Inhibition of Cancer Cell Proliferation
by: Yulin Ren, et al.
Published: (2021-06-01)

<sup>90</sup>Y/<sup>177</sup>Lu-DOTATOC: From Preclinical Studies to Application in Humans
by: Licia Uccelli, et al.
Published: (2021-09-01)

The Provenance of Slovenian Milk Using <sup>87</sup>Sr/<sup>86</sup>Sr Isotope Ratios
by: Staša Hamzić Gregorčič, et al.
Published: (2021-07-01)

A Quantitative <sup>1</sup>H NMR Method for Screening Cannabinoids in CBD Oils
by: Ines Barthlott, et al.
Published: (2021-06-01)

THE ESTIMATION OF RADIATION GAMMA-BACKGROUND AND CONCENTRATION OF LONG-LIVING TECHNOGENIC RADIONUCLIDES OF<sup>137</sup>Cs AND<sup>90</sup>Sr IN SOILS OF CITY-RESORTS OF CAUCASIAN MINERAL WATERS
by: I. S. Pomelyayko
Published: (2017-10-01)

Verification and uniformity control of doses for <sup> 90</sup> Sr/<sup> 90</sup> Y intravascular brachytherapy sources using radiochromic film dosimetry
by: Demir Bayram, et al.
Published: (2008-01-01)