Mitochondrial Dysfunction in Huntington’s Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors

Mitochondrial Dysfunction in Huntington’s Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors

Huntington’s disease (HD) is a neurodegenerative disease caused by an expanded CAG repeat in the huntingtin (HTT) gene, causing the protein to misfold and aggregate. HD progression is characterized by motor impairment and cognitive decline associated with the preferential loss of striatal medium spi...

Full description

Bibliographic Details
Main Authors: Taylor A. Intihar, Elisa A. Martinez, Rocio Gomez-Pastor
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
heat shock factor 1 (HSF1)
mitochondrial dysfunction
Huntington (disease)
p53
PGC-1α
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00103/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00103/full

Similar Items