Coordinated force generation of skeletal myosins in myofilaments through motor coupling

Coordinated force generation of skeletal myosins in myofilaments through motor coupling

Skeletal muscle myosin forms large ensembles to generate force against high loads. Using optical tweezers and simulation Kayaet al. provide experimental evidence for cooperative force generation, and describe how the molecular properties of skeletal myosins are tuned for coordinated power strokes.

Bibliographic Details
Main Authors: Motoshi Kaya, Yoshiaki Tani, Takumi Washio, Toshiaki Hisada, Hideo Higuchi
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms16036
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spelling doaj-ce3987606aff4fb0bbb5abd6897b3bf82021-05-11T07:24:11ZengNature Publishing GroupNature Communications2041-17232017-07-018111310.1038/ncomms16036Coordinated force generation of skeletal myosins in myofilaments through motor couplingMotoshi Kaya0Yoshiaki Tani1Takumi Washio2Toshiaki Hisada3Hideo Higuchi4Deparment of Physics, Graduate School of Science, University of TokyoDeparment of Physics, Graduate School of Science, University of TokyoDepartment of Human and Engineered Environmental Studies, Graduate School of Frontier Science, University of TokyoDepartment of Human and Engineered Environmental Studies, Graduate School of Frontier Science, University of TokyoDeparment of Physics, Graduate School of Science, University of TokyoSkeletal muscle myosin forms large ensembles to generate force against high loads. Using optical tweezers and simulation Kayaet al. provide experimental evidence for cooperative force generation, and describe how the molecular properties of skeletal myosins are tuned for coordinated power strokes.https://doi.org/10.1038/ncomms16036
collection DOAJ
language English
format Article
sources DOAJ
author Motoshi Kaya
Yoshiaki Tani
Takumi Washio
Toshiaki Hisada
Hideo Higuchi
spellingShingle Motoshi Kaya
Yoshiaki Tani
Takumi Washio
Toshiaki Hisada
Hideo Higuchi
Coordinated force generation of skeletal myosins in myofilaments through motor coupling
Nature Communications
author_facet Motoshi Kaya
Yoshiaki Tani
Takumi Washio
Toshiaki Hisada
Hideo Higuchi
author_sort Motoshi Kaya
title Coordinated force generation of skeletal myosins in myofilaments through motor coupling
title_short Coordinated force generation of skeletal myosins in myofilaments through motor coupling
title_full Coordinated force generation of skeletal myosins in myofilaments through motor coupling
title_fullStr Coordinated force generation of skeletal myosins in myofilaments through motor coupling
title_full_unstemmed Coordinated force generation of skeletal myosins in myofilaments through motor coupling
title_sort coordinated force generation of skeletal myosins in myofilaments through motor coupling
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-07-01
description Skeletal muscle myosin forms large ensembles to generate force against high loads. Using optical tweezers and simulation Kayaet al. provide experimental evidence for cooperative force generation, and describe how the molecular properties of skeletal myosins are tuned for coordinated power strokes.
url https://doi.org/10.1038/ncomms16036
work_keys_str_mv AT motoshikaya coordinatedforcegenerationofskeletalmyosinsinmyofilamentsthroughmotorcoupling
AT yoshiakitani coordinatedforcegenerationofskeletalmyosinsinmyofilamentsthroughmotorcoupling
AT takumiwashio coordinatedforcegenerationofskeletalmyosinsinmyofilamentsthroughmotorcoupling
AT toshiakihisada coordinatedforcegenerationofskeletalmyosinsinmyofilamentsthroughmotorcoupling
AT hideohiguchi coordinatedforcegenerationofskeletalmyosinsinmyofilamentsthroughmotorcoupling
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