Generalized Poincaré plots - a new method for evaluation of regimes in cardiac neural control in atrial fibrillation and healthy subjects
Classical Poincaré plot is a standard way to measure nonlinear regulation of cardiovascular control. In our work we propose a generalized form of Poincaré plot where we track correlation between the duration of j preceding and k next RR intervals. The investigation was done in healthy subjects and p...
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doaj-ce3a07b454c54981a835719c7c4086362020-11-25T00:19:41ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2016-02-011010.3389/fnins.2016.00038177762Generalized Poincaré plots - a new method for evaluation of regimes in cardiac neural control in atrial fibrillation and healthy subjectsMirjana M. Platiša0Tijana eBojić1Sinisa U. Pavlovic2Nikola N. Radovanović3Aleksandar eKalauzi4Institute of Biophysics, Faculty of Medicine, University of BelgradeInstitute of Nuclear Sciences Vinča, University of BelgradeClinical Center of Serbia, Faculty of Medicine, University of BelgradeClinical Center of Serbia, Faculty of Medicine, University of BelgradeInstitute for Multidisciplinary Research, University of BelgradeClassical Poincaré plot is a standard way to measure nonlinear regulation of cardiovascular control. In our work we propose a generalized form of Poincaré plot where we track correlation between the duration of j preceding and k next RR intervals. The investigation was done in healthy subjects and patients with atrial fibrillation, by varying j,k ≤ 100. In cases where j=k, in healthy subjects the typical pattern was observed by paths that were substituting scatterplots and that were initiated and ended by loops of Poincaré plot points. This was not the case for atrial fibrillation patients where Poincaré plot had a simple scattered form. More, a typical matrix of Pearson's correlation coefficients, r(j,k), showed different positions of local maxima, depending on the subject's health condition. In both groups, local maxima were grouped into four clusters which probably determined specific regulatory mechanisms according to correlations between the duration of symmetric and asymmetric observed RR intervals. We quantified matrices' degrees of asymmetry and found that they were significantly different: distributed around zero in healthy, while being negative in atrial fibrillation. Also, Pearson's coefficients were higher in healthy than in atrial fibrillation or in signals with reshuffled intervals. Our hypothesis is that by this novel method we can observe heart rate regimes typical for baseline conditions and defence reaction in healthy subjects. These data indicate that neural control mechanisms of heart rate are operating in healthy subjects in contrast with atrial fibrillation, identifying it as the state of risk for stress-dependent pathologies. Regulatory regimes of heart rate can be further quantified and explored by the proposed novel method.http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00038/fullAtrial FibrillationAutonomic Nervous SystemHeart RatePoincaré plotindexes of asymmetryneural control regimes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mirjana M. Platiša Tijana eBojić Sinisa U. Pavlovic Nikola N. Radovanović Aleksandar eKalauzi |
spellingShingle |
Mirjana M. Platiša Tijana eBojić Sinisa U. Pavlovic Nikola N. Radovanović Aleksandar eKalauzi Generalized Poincaré plots - a new method for evaluation of regimes in cardiac neural control in atrial fibrillation and healthy subjects Frontiers in Neuroscience Atrial Fibrillation Autonomic Nervous System Heart Rate Poincaré plot indexes of asymmetry neural control regimes |
author_facet |
Mirjana M. Platiša Tijana eBojić Sinisa U. Pavlovic Nikola N. Radovanović Aleksandar eKalauzi |
author_sort |
Mirjana M. Platiša |
title |
Generalized Poincaré plots - a new method for evaluation of regimes in cardiac neural control in atrial fibrillation and healthy subjects |
title_short |
Generalized Poincaré plots - a new method for evaluation of regimes in cardiac neural control in atrial fibrillation and healthy subjects |
title_full |
Generalized Poincaré plots - a new method for evaluation of regimes in cardiac neural control in atrial fibrillation and healthy subjects |
title_fullStr |
Generalized Poincaré plots - a new method for evaluation of regimes in cardiac neural control in atrial fibrillation and healthy subjects |
title_full_unstemmed |
Generalized Poincaré plots - a new method for evaluation of regimes in cardiac neural control in atrial fibrillation and healthy subjects |
title_sort |
generalized poincaré plots - a new method for evaluation of regimes in cardiac neural control in atrial fibrillation and healthy subjects |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2016-02-01 |
description |
Classical Poincaré plot is a standard way to measure nonlinear regulation of cardiovascular control. In our work we propose a generalized form of Poincaré plot where we track correlation between the duration of j preceding and k next RR intervals. The investigation was done in healthy subjects and patients with atrial fibrillation, by varying j,k ≤ 100. In cases where j=k, in healthy subjects the typical pattern was observed by paths that were substituting scatterplots and that were initiated and ended by loops of Poincaré plot points. This was not the case for atrial fibrillation patients where Poincaré plot had a simple scattered form. More, a typical matrix of Pearson's correlation coefficients, r(j,k), showed different positions of local maxima, depending on the subject's health condition. In both groups, local maxima were grouped into four clusters which probably determined specific regulatory mechanisms according to correlations between the duration of symmetric and asymmetric observed RR intervals. We quantified matrices' degrees of asymmetry and found that they were significantly different: distributed around zero in healthy, while being negative in atrial fibrillation. Also, Pearson's coefficients were higher in healthy than in atrial fibrillation or in signals with reshuffled intervals. Our hypothesis is that by this novel method we can observe heart rate regimes typical for baseline conditions and defence reaction in healthy subjects. These data indicate that neural control mechanisms of heart rate are operating in healthy subjects in contrast with atrial fibrillation, identifying it as the state of risk for stress-dependent pathologies. Regulatory regimes of heart rate can be further quantified and explored by the proposed novel method. |
topic |
Atrial Fibrillation Autonomic Nervous System Heart Rate Poincaré plot indexes of asymmetry neural control regimes |
url |
http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00038/full |
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