Distinct modulation of angiotensin II-induced early left ventricular hypertrophic gene programming by dietary fat type
Long-term dietary fatty acid intake alters the development of left ventricular hypertrophy, but the linking signaling pathways are unclear. We studied the role and underlying signaling mechanisms of dietary fat intake in the early phase of the hypertrophic process. Rats assigned for 4 weeks of high-...
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doaj-ce3ba7e7b9904ebb9d070bbc17279bcb2021-04-27T04:44:32ZengElsevierJournal of Lipid Research0022-22752006-06-0147612191226Distinct modulation of angiotensin II-induced early left ventricular hypertrophic gene programming by dietary fat typeGaébor Foäldes0Szilvia Vajda1Zoltaén Lakoé-Futoé2Balaézs Saérmaén3Reéka Skoumal4Mika Ilves5Rudolf deChâtel6Istvaén Karaédi7Mikloés Toéth8Heikki Ruskoaho9Istvaén Lepraén10First Department of Medicine, Semmelweis University, Budapest, HungaryDepartment of Pharmacology and Pharmacotherapy, Szeged University, Szeged, HungaryFirst Department of Medicine, Semmelweis University, Budapest, HungaryFirst Department of Medicine, Semmelweis University, Budapest, HungaryFirst Department of Medicine, Semmelweis University, Budapest, HungaryDepartment of Physiology, Biocenter Oulu, University of Oulu, Oulu, FinlandFirst Department of Medicine, Semmelweis University, Budapest, HungaryThird Department of Medicine, Semmelweis University, Budapest, HungaryFirst Department of Medicine, Semmelweis University, Budapest, HungaryDepartments of Pharmacology and Toxicology, Biocenter Oulu, University of Oulu, Oulu, FinlandDepartment of Pharmacology and Pharmacotherapy, Szeged University, Szeged, HungaryLong-term dietary fatty acid intake alters the development of left ventricular hypertrophy, but the linking signaling pathways are unclear. We studied the role and underlying signaling mechanisms of dietary fat intake in the early phase of the hypertrophic process. Rats assigned for 4 weeks of high-oil, high-fat, or standard diet were subjected to angiotensin II (Ang II; 33 μg/kg/h, subcutaneous) or vehicle infusion for 24 h. The Ang II-induced increase in left ventricular mRNA levels of hypertrophy-associated genes was higher in rats fed the high-oil diet compared with the standard diet. Western blotting revealed that, in parallel with changes in gene expression, the high-oil diet increased c-Jun N-terminal kinase phosphorylation (P < 0.001). Ang II increased p38 mitogen-activated protein kinase (MAPK) phosphorylation in rats fed the high-fat diet (3-fold; P < 0.01). The increase in transcription factor activator protein-1 (AP-1) DNA binding activity in response to Ang II was higher in rats fed the high-oil diet compared with those fed the standard diet (P < 0.001). Ang II downregulated inducible nitric oxide synthase mRNA levels in fatty acid-supplemented groups compared with the standard diet group. These results show that dietary fat type modulates the early activation of hypertrophic genes in pressure-overloaded myocardium involving the distinct activation of AP-1 and MAPK signal transduction pathways.http://www.sciencedirect.com/science/article/pii/S0022227520332211cardiac hypertrophyfatty acidssignal transductionmitogen-activated protein kinases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gaébor Foäldes Szilvia Vajda Zoltaén Lakoé-Futoé Balaézs Saérmaén Reéka Skoumal Mika Ilves Rudolf deChâtel Istvaén Karaédi Mikloés Toéth Heikki Ruskoaho Istvaén Lepraén |
spellingShingle |
Gaébor Foäldes Szilvia Vajda Zoltaén Lakoé-Futoé Balaézs Saérmaén Reéka Skoumal Mika Ilves Rudolf deChâtel Istvaén Karaédi Mikloés Toéth Heikki Ruskoaho Istvaén Lepraén Distinct modulation of angiotensin II-induced early left ventricular hypertrophic gene programming by dietary fat type Journal of Lipid Research cardiac hypertrophy fatty acids signal transduction mitogen-activated protein kinases |
author_facet |
Gaébor Foäldes Szilvia Vajda Zoltaén Lakoé-Futoé Balaézs Saérmaén Reéka Skoumal Mika Ilves Rudolf deChâtel Istvaén Karaédi Mikloés Toéth Heikki Ruskoaho Istvaén Lepraén |
author_sort |
Gaébor Foäldes |
title |
Distinct modulation of angiotensin II-induced early left ventricular hypertrophic gene programming by dietary fat type |
title_short |
Distinct modulation of angiotensin II-induced early left ventricular hypertrophic gene programming by dietary fat type |
title_full |
Distinct modulation of angiotensin II-induced early left ventricular hypertrophic gene programming by dietary fat type |
title_fullStr |
Distinct modulation of angiotensin II-induced early left ventricular hypertrophic gene programming by dietary fat type |
title_full_unstemmed |
Distinct modulation of angiotensin II-induced early left ventricular hypertrophic gene programming by dietary fat type |
title_sort |
distinct modulation of angiotensin ii-induced early left ventricular hypertrophic gene programming by dietary fat type |
publisher |
Elsevier |
series |
Journal of Lipid Research |
issn |
0022-2275 |
publishDate |
2006-06-01 |
description |
Long-term dietary fatty acid intake alters the development of left ventricular hypertrophy, but the linking signaling pathways are unclear. We studied the role and underlying signaling mechanisms of dietary fat intake in the early phase of the hypertrophic process. Rats assigned for 4 weeks of high-oil, high-fat, or standard diet were subjected to angiotensin II (Ang II; 33 μg/kg/h, subcutaneous) or vehicle infusion for 24 h. The Ang II-induced increase in left ventricular mRNA levels of hypertrophy-associated genes was higher in rats fed the high-oil diet compared with the standard diet. Western blotting revealed that, in parallel with changes in gene expression, the high-oil diet increased c-Jun N-terminal kinase phosphorylation (P < 0.001). Ang II increased p38 mitogen-activated protein kinase (MAPK) phosphorylation in rats fed the high-fat diet (3-fold; P < 0.01). The increase in transcription factor activator protein-1 (AP-1) DNA binding activity in response to Ang II was higher in rats fed the high-oil diet compared with those fed the standard diet (P < 0.001). Ang II downregulated inducible nitric oxide synthase mRNA levels in fatty acid-supplemented groups compared with the standard diet group. These results show that dietary fat type modulates the early activation of hypertrophic genes in pressure-overloaded myocardium involving the distinct activation of AP-1 and MAPK signal transduction pathways. |
topic |
cardiac hypertrophy fatty acids signal transduction mitogen-activated protein kinases |
url |
http://www.sciencedirect.com/science/article/pii/S0022227520332211 |
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