Unsaturated fatty acid salts remove biofilms on dentures
Abstract Candidiasis-causing Candida sp. forms biofilms with various oral bacteria in the dentures of the elderly, making it harder to kill and remove the microorganism due to the extracellular polymeric substances. We found that biofilms on dentures can effectively be removed by immersion in an uns...
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2021-06-01
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Online Access: | https://doi.org/10.1038/s41598-021-92044-y |
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doaj-ce3fdfcb442d4d638fbf2007aa7fc93f2021-06-20T11:32:39ZengNature Publishing GroupScientific Reports2045-23222021-06-0111111010.1038/s41598-021-92044-yUnsaturated fatty acid salts remove biofilms on denturesTeruyuki Hara0Atsunori Sonoi1Takuya Handa2Masayuki Okamoto3Eri Kaneko4Reiko Ikeda5Taichi Habe6Hidetake Fujinaka7Shigeto Inoue8Tetsuo Ichikawa9Analytical Science Research Laboratories, Kao CorporationPersonal Health Care Products Research Laboratories, Kao CorporationPersonal Health Care Products Research Laboratories, Kao CorporationAnalytical Science Research Laboratories, Kao CorporationAnalytical Science Research Laboratories, Kao CorporationAnalytical Science Research Laboratories, Kao CorporationAnalytical Science Research Laboratories, Kao CorporationPersonal Health Care Products Research Laboratories, Kao CorporationAnalytical Science Research Laboratories, Kao CorporationDepartment of Prosthodontics and Oral Rehabilitation, Graduate School of Biomedical Sciences, Tokushima UniversityAbstract Candidiasis-causing Candida sp. forms biofilms with various oral bacteria in the dentures of the elderly, making it harder to kill and remove the microorganism due to the extracellular polymeric substances. We found that biofilms on dentures can effectively be removed by immersion in an unsaturated fatty acid salt solution. Using optical coherence tomography to observe the progression of biofilm removal by the fatty acid salt solution, we were able to determine that the removal was accompanied by the production of gaps at the interface between the biofilm and denture resin. Furthermore, microstructural electron microscopy observations and time-of-flight secondary ion mass spectrometry elucidated the site of action, revealing that localization of the fatty acid salt at the biofilm/denture-resin interface is an important factor.https://doi.org/10.1038/s41598-021-92044-y |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Teruyuki Hara Atsunori Sonoi Takuya Handa Masayuki Okamoto Eri Kaneko Reiko Ikeda Taichi Habe Hidetake Fujinaka Shigeto Inoue Tetsuo Ichikawa |
spellingShingle |
Teruyuki Hara Atsunori Sonoi Takuya Handa Masayuki Okamoto Eri Kaneko Reiko Ikeda Taichi Habe Hidetake Fujinaka Shigeto Inoue Tetsuo Ichikawa Unsaturated fatty acid salts remove biofilms on dentures Scientific Reports |
author_facet |
Teruyuki Hara Atsunori Sonoi Takuya Handa Masayuki Okamoto Eri Kaneko Reiko Ikeda Taichi Habe Hidetake Fujinaka Shigeto Inoue Tetsuo Ichikawa |
author_sort |
Teruyuki Hara |
title |
Unsaturated fatty acid salts remove biofilms on dentures |
title_short |
Unsaturated fatty acid salts remove biofilms on dentures |
title_full |
Unsaturated fatty acid salts remove biofilms on dentures |
title_fullStr |
Unsaturated fatty acid salts remove biofilms on dentures |
title_full_unstemmed |
Unsaturated fatty acid salts remove biofilms on dentures |
title_sort |
unsaturated fatty acid salts remove biofilms on dentures |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-06-01 |
description |
Abstract Candidiasis-causing Candida sp. forms biofilms with various oral bacteria in the dentures of the elderly, making it harder to kill and remove the microorganism due to the extracellular polymeric substances. We found that biofilms on dentures can effectively be removed by immersion in an unsaturated fatty acid salt solution. Using optical coherence tomography to observe the progression of biofilm removal by the fatty acid salt solution, we were able to determine that the removal was accompanied by the production of gaps at the interface between the biofilm and denture resin. Furthermore, microstructural electron microscopy observations and time-of-flight secondary ion mass spectrometry elucidated the site of action, revealing that localization of the fatty acid salt at the biofilm/denture-resin interface is an important factor. |
url |
https://doi.org/10.1038/s41598-021-92044-y |
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