The Efficacy of Silymarin and Vitamin E in Non-Alcoholic Fatty Liver Disease: A Clinical Trial
Abstract Objective: Nowadays, lifestyle modification is the best treatment recommended to patients with the nonalcoholic fatty liver disease (NAFLD). The therapeutic effects of vitamin E and silybin on liver functions were documented. The present study was conducted to examine the effect of silymari...
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Shahid Sadoughi University of Medical Sciences
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doaj-ce54087cb9534ae9a2883c131847a5912020-11-25T03:41:10ZengShahid Sadoughi University of Medical SciencesIranian Journal of Diabetes and Obesity 2008-67922345-22502020-06-011228489The Efficacy of Silymarin and Vitamin E in Non-Alcoholic Fatty Liver Disease: A Clinical TrialMohsen Akhondi-Meybodi0Mahmoud Baghbanian1Abolfazl Namazi2 Associate Professor of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran Associate Professor of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran Internist of Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Science, Yazd, Iran Abstract Objective: Nowadays, lifestyle modification is the best treatment recommended to patients with the nonalcoholic fatty liver disease (NAFLD). The therapeutic effects of vitamin E and silybin on liver functions were documented. The present study was conducted to examine the effect of silymarin and vitamin E on patients with NAFLD. Materials and Methods: From September 2014 to March 2015, clinical trial was conducted on 92 patients with NAFLD at 2 Shahid Sadoughi university clinical research centers. Sampling was based on convenient method. There were no randomization or blinding in this study, but two types of treatments were compared. The patients were divided in two groups of daily intake of vitamin E (400 IU) and Silymarin 280 mg for four months. Alanine aminotransferase (ALT) and liver ultrasonography were done at baseline and after four months. Results: Eighty patients completed the course of treatment successfully .After 4 months, both groups had experienced a significant reduction in their serum ALT levels. The mean change in the ALT level from the baseline was -31.6 U/L in the silymarin group vs. -15.1 U/L in the vitamin E group (P-value= 0.07). Treatment with silymarin was more effective than vitamin E (P-value< 0.0001). The mean ALT level changed to normal was 55.0% (22 of 40 patients )in the silymarin group, while it was 45.0% (18 of 40 cases) in the vitamin E group (P-value= 0.04). Conclusion: The treatment of NAFLD with silymarin appears to be significantly effective in biochemical improvement whereas treatment with vitamin E improves ultrasonographic parameters.http://ijdo.ssu.ac.ir/article-1-559-en.htmlnonalcoholic fatty liver diseasesilymarinvitamin eclinical trial |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohsen Akhondi-Meybodi Mahmoud Baghbanian Abolfazl Namazi |
spellingShingle |
Mohsen Akhondi-Meybodi Mahmoud Baghbanian Abolfazl Namazi The Efficacy of Silymarin and Vitamin E in Non-Alcoholic Fatty Liver Disease: A Clinical Trial Iranian Journal of Diabetes and Obesity nonalcoholic fatty liver disease silymarin vitamin e clinical trial |
author_facet |
Mohsen Akhondi-Meybodi Mahmoud Baghbanian Abolfazl Namazi |
author_sort |
Mohsen Akhondi-Meybodi |
title |
The Efficacy of Silymarin and Vitamin E in Non-Alcoholic Fatty Liver Disease: A Clinical Trial |
title_short |
The Efficacy of Silymarin and Vitamin E in Non-Alcoholic Fatty Liver Disease: A Clinical Trial |
title_full |
The Efficacy of Silymarin and Vitamin E in Non-Alcoholic Fatty Liver Disease: A Clinical Trial |
title_fullStr |
The Efficacy of Silymarin and Vitamin E in Non-Alcoholic Fatty Liver Disease: A Clinical Trial |
title_full_unstemmed |
The Efficacy of Silymarin and Vitamin E in Non-Alcoholic Fatty Liver Disease: A Clinical Trial |
title_sort |
efficacy of silymarin and vitamin e in non-alcoholic fatty liver disease: a clinical trial |
publisher |
Shahid Sadoughi University of Medical Sciences |
series |
Iranian Journal of Diabetes and Obesity |
issn |
2008-6792 2345-2250 |
publishDate |
2020-06-01 |
description |
Abstract
Objective: Nowadays, lifestyle modification is the best treatment recommended to patients with the nonalcoholic fatty liver disease (NAFLD). The therapeutic effects of vitamin E and silybin on liver functions were documented. The present study was conducted to examine the effect of silymarin and vitamin E on patients with NAFLD.
Materials and Methods: From September 2014 to March 2015, clinical trial was conducted on 92 patients with NAFLD at 2 Shahid Sadoughi university clinical research centers. Sampling was based on convenient method. There were no randomization or blinding in this study, but two types of treatments were compared. The patients were divided in two groups of daily intake of vitamin E (400 IU) and Silymarin 280 mg for four months. Alanine aminotransferase (ALT) and liver ultrasonography were done at baseline and after four months.
Results: Eighty patients completed the course of treatment successfully .After 4 months, both groups had experienced a significant reduction in their serum ALT levels. The mean change in the ALT level from the baseline was -31.6 U/L in the silymarin group vs. -15.1 U/L in the vitamin E group (P-value= 0.07). Treatment with silymarin was more effective than vitamin E (P-value< 0.0001). The mean ALT level changed to normal was 55.0% (22 of 40 patients )in the silymarin group, while it was 45.0% (18 of 40 cases) in the vitamin E group (P-value= 0.04).
Conclusion: The treatment of NAFLD with silymarin appears to be significantly effective in biochemical improvement whereas treatment with vitamin E improves ultrasonographic parameters. |
topic |
nonalcoholic fatty liver disease silymarin vitamin e clinical trial |
url |
http://ijdo.ssu.ac.ir/article-1-559-en.html |
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