Identification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses.
Defining the components of an HIV immunogen that could induce effective CD8+ T cell responses is critical to vaccine development. We addressed this question by investigating the viral targets of CD8+ T cells that potently inhibit HIV replication in vitro, as this is highly predictive of virus contro...
Main Authors: | Gemma Hancock, Hongbing Yang, Elisabeth Yorke, Emma Wainwright, Victoria Bourne, Alyse Frisbee, Tamika L Payne, Mark Berrong, Guido Ferrari, Denis Chopera, Tomas Hanke, Beatriz Mothe, Christian Brander, M Juliana McElrath, Andrew McMichael, Nilu Goonetilleke, Georgia D Tomaras, Nicole Frahm, Lucy Dorrell |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-02-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC4344337?pdf=render |
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