The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus
Developing T cells commit to either CD4/helper or CD8/cytotoxic lineage in the thymus, but how CD4 and CD8 coreceptors and TCR signaling dictate this selection process is still unclear. Here the authors use single cell RNA sequencing of mouse thymocytes to show that, in selection intermediates, TCR...
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2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20306-w |
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doaj-ce6d54e4a05749d99545339b720e286a2021-01-10T12:18:03ZengNature Publishing GroupNature Communications2041-17232021-01-0112111410.1038/s41467-020-20306-wThe order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymusMohammad M. Karimi0Ya Guo1Xiaokai Cui2Husayn A. Pallikonda3Veronika Horková4Yi-Fang Wang5Sara Ruiz Gil6Gustavo Rodriguez-Esteban7Irene Robles-Rebollo8Ludovica Bruno9Radina Georgieva10Bhavik Patel11James Elliott12Marian H. Dore13Danielle Dauphars14Michael S. Krangel15Boris Lenhard16Holger Heyn17Amanda G. Fisher18Ondřej Štěpánek19Matthias Merkenschlager20MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonMRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonMRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonMRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonLaboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of SciencesMRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonCNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST)CNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST)MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonMRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonMRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonMRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonMRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonMRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonDepartment of Immunology, Duke University Medical CenterDepartment of Immunology, Duke University Medical CenterMRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonCNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST)MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonLaboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of SciencesMRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonDeveloping T cells commit to either CD4/helper or CD8/cytotoxic lineage in the thymus, but how CD4 and CD8 coreceptors and TCR signaling dictate this selection process is still unclear. Here the authors use single cell RNA sequencing of mouse thymocytes to show that, in selection intermediates, TCR signaling strength informs coreceptor expression timing.https://doi.org/10.1038/s41467-020-20306-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Mohammad M. Karimi Ya Guo Xiaokai Cui Husayn A. Pallikonda Veronika Horková Yi-Fang Wang Sara Ruiz Gil Gustavo Rodriguez-Esteban Irene Robles-Rebollo Ludovica Bruno Radina Georgieva Bhavik Patel James Elliott Marian H. Dore Danielle Dauphars Michael S. Krangel Boris Lenhard Holger Heyn Amanda G. Fisher Ondřej Štěpánek Matthias Merkenschlager |
| spellingShingle |
Mohammad M. Karimi Ya Guo Xiaokai Cui Husayn A. Pallikonda Veronika Horková Yi-Fang Wang Sara Ruiz Gil Gustavo Rodriguez-Esteban Irene Robles-Rebollo Ludovica Bruno Radina Georgieva Bhavik Patel James Elliott Marian H. Dore Danielle Dauphars Michael S. Krangel Boris Lenhard Holger Heyn Amanda G. Fisher Ondřej Štěpánek Matthias Merkenschlager The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus Nature Communications |
| author_facet |
Mohammad M. Karimi Ya Guo Xiaokai Cui Husayn A. Pallikonda Veronika Horková Yi-Fang Wang Sara Ruiz Gil Gustavo Rodriguez-Esteban Irene Robles-Rebollo Ludovica Bruno Radina Georgieva Bhavik Patel James Elliott Marian H. Dore Danielle Dauphars Michael S. Krangel Boris Lenhard Holger Heyn Amanda G. Fisher Ondřej Štěpánek Matthias Merkenschlager |
| author_sort |
Mohammad M. Karimi |
| title |
The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus |
| title_short |
The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus |
| title_full |
The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus |
| title_fullStr |
The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus |
| title_full_unstemmed |
The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus |
| title_sort |
order and logic of cd4 versus cd8 lineage choice and differentiation in mouse thymus |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-01-01 |
| description |
Developing T cells commit to either CD4/helper or CD8/cytotoxic lineage in the thymus, but how CD4 and CD8 coreceptors and TCR signaling dictate this selection process is still unclear. Here the authors use single cell RNA sequencing of mouse thymocytes to show that, in selection intermediates, TCR signaling strength informs coreceptor expression timing. |
| url |
https://doi.org/10.1038/s41467-020-20306-w |
| work_keys_str_mv |
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