Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera

Five new phenolic compounds rynchopeterines A–E (1–5), in addition to thirteen known phenolics, were isolated from Blaps rynchopetera Fairmaire, a kind of medicinal insect utilized by the Yi Nationality in Yunnan Province of China. Their structures were established on the basis of extensive spectros...

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Main Authors:	Huai Xiao, Tian-Peng Yin, Jian-Wei Dong, Xiu-Mei Wu, Qing Luo, Jian-Rong Luo, Le Cai, Zhong-Tao Ding
Format:	Article
Language:	English
Published:	MDPI AG 2017-08-01
Series:	Molecules
Subjects:	Blaps rynchopetera chemical constituents phenolic rynchopeterines A–E antioxidant anti-tumor
Online Access:	https://www.mdpi.com/1420-3049/22/8/1301

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spelling	doaj-ce750c6e4a1a4785880318c3cca963382020-11-25T00:40:21ZengMDPI AGMolecules1420-30492017-08-01228130110.3390/molecules22081301molecules22081301Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopeteraHuai Xiao0Tian-Peng Yin1Jian-Wei Dong2Xiu-Mei Wu3Qing Luo4Jian-Rong Luo5Le Cai6Zhong-Tao Ding7Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, ChinaFunctional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, ChinaFunctional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, ChinaYunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000, ChinaYunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000, ChinaYunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000, ChinaFunctional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, ChinaFunctional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, ChinaFive new phenolic compounds rynchopeterines A–E (1–5), in addition to thirteen known phenolics, were isolated from Blaps rynchopetera Fairmaire, a kind of medicinal insect utilized by the Yi Nationality in Yunnan Province of China. Their structures were established on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-MS, IR) along with calculated electronic circular dichroism method. Rynchopeterines A–E (1–4) exhibited significant antioxidant activities with IC50 values of 7.67–12.3 μg/mL measured by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Besides, rynchopeterines B (2) and C (3) showed mild cytotoxicity against tumor cell Caco-2 and A549.https://www.mdpi.com/1420-3049/22/8/1301Blaps rynchopeterachemical constituentsphenolicrynchopeterines A–Eantioxidantanti-tumor
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Huai Xiao Tian-Peng Yin Jian-Wei Dong Xiu-Mei Wu Qing Luo Jian-Rong Luo Le Cai Zhong-Tao Ding
spellingShingle	Huai Xiao Tian-Peng Yin Jian-Wei Dong Xiu-Mei Wu Qing Luo Jian-Rong Luo Le Cai Zhong-Tao Ding Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera Molecules Blaps rynchopetera chemical constituents phenolic rynchopeterines A–E antioxidant anti-tumor
author_facet	Huai Xiao Tian-Peng Yin Jian-Wei Dong Xiu-Mei Wu Qing Luo Jian-Rong Luo Le Cai Zhong-Tao Ding
author_sort	Huai Xiao
title	Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera
title_short	Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera
title_full	Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera
title_fullStr	Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera
title_full_unstemmed	Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera
title_sort	five new phenolic compounds with antioxidant activities from the medicinal insect blaps rynchopetera
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2017-08-01
description	Five new phenolic compounds rynchopeterines A–E (1–5), in addition to thirteen known phenolics, were isolated from Blaps rynchopetera Fairmaire, a kind of medicinal insect utilized by the Yi Nationality in Yunnan Province of China. Their structures were established on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-MS, IR) along with calculated electronic circular dichroism method. Rynchopeterines A–E (1–4) exhibited significant antioxidant activities with IC50 values of 7.67–12.3 μg/mL measured by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Besides, rynchopeterines B (2) and C (3) showed mild cytotoxicity against tumor cell Caco-2 and A549.
topic	Blaps rynchopetera chemical constituents phenolic rynchopeterines A–E antioxidant anti-tumor
url	https://www.mdpi.com/1420-3049/22/8/1301
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Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera

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