White matter connectivity and aerobic fitness in male adolescents
Exercise has been shown to have positive effects on the brain and behavior throughout various stages of the lifespan. However, little is known about the impact of exercise on neurodevelopment during the adolescent years, particularly with regard to white matter microstructure, as assessed by diffusi...
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doaj-ce87bd7e556a43f9b01881353befbf9a2020-11-24T21:10:29ZengElsevierDevelopmental Cognitive Neuroscience1878-92931878-93072014-01-017C657510.1016/j.dcn.2013.11.003White matter connectivity and aerobic fitness in male adolescentsMegan M. Herting0John B. Colby1Elizabeth R. Sowell2Bonnie J. Nagel3Department of Pediatrics, Keck School of Medicine at USC/Children's Hospital of Los Angeles, Los Angeles, CA, USADavid Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USADepartment of Pediatrics, Keck School of Medicine at USC/Children's Hospital of Los Angeles, Los Angeles, CA, USADepartment of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mail-Code: DC7P, Portland, OR 97239, USAExercise has been shown to have positive effects on the brain and behavior throughout various stages of the lifespan. However, little is known about the impact of exercise on neurodevelopment during the adolescent years, particularly with regard to white matter microstructure, as assessed by diffusion tensor imaging (DTI). Both tract-based spatial statistics (TBSS) and tractography-based along-tract statistics were utilized to examine the relationship between white matter microstructure and aerobic exercise in adolescent males, ages 15–18. Furthermore, we examined the data by both (1) grouping individuals based on aerobic fitness self-reports (high fit (HF) vs. low fit (LF)), and (2) using VO2 peak as a continuous variable across the entire sample. Results showed that HF youth had an overall higher number of streamline counts compared to LF peers, which was driven by group differences in corticospinal tract (CST) and anterior corpus callosum (Fminor). In addition, VO2 peak was negatively related to FA in the left CST. Together, these results suggest that aerobic fitness relates to white matter connectivity and microstructure in tracts carrying frontal and motor fibers during adolescence. Furthermore, the current study highlights the importance of considering the environmental factor of aerobic exercise when examining adolescent brain development.http://www.sciencedirect.com/science/article/pii/S1878929313000959AdolescenceAerobic exerciseWhite matterDiffusion tensor imagingTractography |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Megan M. Herting John B. Colby Elizabeth R. Sowell Bonnie J. Nagel |
spellingShingle |
Megan M. Herting John B. Colby Elizabeth R. Sowell Bonnie J. Nagel White matter connectivity and aerobic fitness in male adolescents Developmental Cognitive Neuroscience Adolescence Aerobic exercise White matter Diffusion tensor imaging Tractography |
author_facet |
Megan M. Herting John B. Colby Elizabeth R. Sowell Bonnie J. Nagel |
author_sort |
Megan M. Herting |
title |
White matter connectivity and aerobic fitness in male adolescents |
title_short |
White matter connectivity and aerobic fitness in male adolescents |
title_full |
White matter connectivity and aerobic fitness in male adolescents |
title_fullStr |
White matter connectivity and aerobic fitness in male adolescents |
title_full_unstemmed |
White matter connectivity and aerobic fitness in male adolescents |
title_sort |
white matter connectivity and aerobic fitness in male adolescents |
publisher |
Elsevier |
series |
Developmental Cognitive Neuroscience |
issn |
1878-9293 1878-9307 |
publishDate |
2014-01-01 |
description |
Exercise has been shown to have positive effects on the brain and behavior throughout various stages of the lifespan. However, little is known about the impact of exercise on neurodevelopment during the adolescent years, particularly with regard to white matter microstructure, as assessed by diffusion tensor imaging (DTI). Both tract-based spatial statistics (TBSS) and tractography-based along-tract statistics were utilized to examine the relationship between white matter microstructure and aerobic exercise in adolescent males, ages 15–18. Furthermore, we examined the data by both (1) grouping individuals based on aerobic fitness self-reports (high fit (HF) vs. low fit (LF)), and (2) using VO2 peak as a continuous variable across the entire sample. Results showed that HF youth had an overall higher number of streamline counts compared to LF peers, which was driven by group differences in corticospinal tract (CST) and anterior corpus callosum (Fminor). In addition, VO2 peak was negatively related to FA in the left CST. Together, these results suggest that aerobic fitness relates to white matter connectivity and microstructure in tracts carrying frontal and motor fibers during adolescence. Furthermore, the current study highlights the importance of considering the environmental factor of aerobic exercise when examining adolescent brain development. |
topic |
Adolescence Aerobic exercise White matter Diffusion tensor imaging Tractography |
url |
http://www.sciencedirect.com/science/article/pii/S1878929313000959 |
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