Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5.
Viral infections are often accompanied by pulmonary microvascular leakage and vascular endothelial dysfunction via mechanisms that are not completely defined. Here, we investigated the effect of the Toll-like receptor 3 (TLR3) ligand polyinosinic-polycytidylic acid [Poly(I:C)], a synthetic analog of...
Main Authors: | Li-Yun Huang, Christine Stuart, Kazuyo Takeda, Felice D'Agnillo, Basil Golding |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4978501?pdf=render |
Similar Items
-
Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions.
by: Felice D'Agnillo, et al.
Published: (2013-01-01) -
Claudin Loss-of-Function Disrupts Tight Junctions and Impairs Amelogenesis
by: Claire Bardet, et al.
Published: (2017-05-01) -
Anthrax Lethal Toxin-Mediated Disruption of Endothelial VE-Cadherin Is Attenuated by Inhibition of the Rho-Associated Kinase Pathway
by: Jason M. Warfel, et al.
Published: (2011-10-01) -
Lipopolysaccharide disrupts the milk-blood barrier by modulating claudins in mammary alveolar tight junctions.
by: Ken Kobayashi, et al.
Published: (2013-01-01) -
Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases.
by: Paul R Clark, et al.
Published: (2015-01-01)