Different types of amyloid concomitantly present in the same patients
Different types of amyloid concomitantly present in the same patient is believed to be improbable. We reported four cases of patients with plasma cell disorders who were found to have biopsy proven concomitant different types of amyloid fibrils deposition. We characterized amyloid fibrils using imm...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
PAGEPress Publications
2019-12-01
|
Series: | Hematology Reports |
Subjects: | |
Online Access: | https://pagepress.org/journals/index.php/hr/article/view/7996 |
id |
doaj-ce95b646304e4e5b850832cf35f76cc0 |
---|---|
record_format |
Article |
spelling |
doaj-ce95b646304e4e5b850832cf35f76cc02020-11-25T03:56:02ZengPAGEPress PublicationsHematology Reports2038-83222038-83302019-12-0111410.4081/hr.2019.7996Different types of amyloid concomitantly present in the same patientsFrancesca Martini0Gabriele Buda1Vincenzo De Tata2Sara Galimberti3Enrico Orciuolo4Matilde Masini5Mario Petrini6Department of Clinical and Experimental Medicine, U.O. Hematology, University of PisaDepartment of Clinical and Experimental Medicine, U.O. Hematology, University of PisaDepartment of Clinical and Experimental Medicine, U.O. Hematology, University of PisaDepartment of Clinical and Experimental Medicine, U.O. Hematology, University of PisaDepartment of Clinical and Experimental Medicine, U.O. Hematology, University of PisaDepartment of Clinical and Experimental Medicine, U.O. Hematology, University of PisaDepartment of Clinical and Experimental Medicine, U.O. Hematology, University of Pisa Different types of amyloid concomitantly present in the same patient is believed to be improbable. We reported four cases of patients with plasma cell disorders who were found to have biopsy proven concomitant different types of amyloid fibrils deposition. We characterized amyloid fibrils using immunogold electron microscopy. There is lack of experience in the treatment of these frail and elderly patients, who are on the threshold between necessity of chemotherapy for AL amyloidosis and necessity to avoid harmful treatment related toxicity. All patients with a systemic amyloid syndrome require therapy to prevent deposition of amyloid in other organs and prevent progressive organ failure. Stem cell transplant (SCT) is preferred, but only 20% of patients are eligible Requirements for safe SCT include systolic blood pressure >90 mm Hg, troponin T <0.06 ng/mL, age <70 years, and serum creatinine ≤1.7 mg/dL Nontransplant candidates can be offered melphalandexamethasone or cyclophosphamide-bortezomibdexamethasone. https://pagepress.org/journals/index.php/hr/article/view/7996Amyloidosis, plasma cell dyscrasia, electron microscopy, multiple myeloma, rheumatologic disease, cardiovascular disease, renal disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francesca Martini Gabriele Buda Vincenzo De Tata Sara Galimberti Enrico Orciuolo Matilde Masini Mario Petrini |
spellingShingle |
Francesca Martini Gabriele Buda Vincenzo De Tata Sara Galimberti Enrico Orciuolo Matilde Masini Mario Petrini Different types of amyloid concomitantly present in the same patients Hematology Reports Amyloidosis, plasma cell dyscrasia, electron microscopy, multiple myeloma, rheumatologic disease, cardiovascular disease, renal disease |
author_facet |
Francesca Martini Gabriele Buda Vincenzo De Tata Sara Galimberti Enrico Orciuolo Matilde Masini Mario Petrini |
author_sort |
Francesca Martini |
title |
Different types of amyloid concomitantly present in the same patients |
title_short |
Different types of amyloid concomitantly present in the same patients |
title_full |
Different types of amyloid concomitantly present in the same patients |
title_fullStr |
Different types of amyloid concomitantly present in the same patients |
title_full_unstemmed |
Different types of amyloid concomitantly present in the same patients |
title_sort |
different types of amyloid concomitantly present in the same patients |
publisher |
PAGEPress Publications |
series |
Hematology Reports |
issn |
2038-8322 2038-8330 |
publishDate |
2019-12-01 |
description |
Different types of amyloid concomitantly present in the same patient is believed to be improbable. We reported four cases of patients with plasma cell disorders who were found to have biopsy proven concomitant different types of amyloid fibrils deposition. We characterized amyloid fibrils using immunogold electron microscopy. There is lack of experience in the treatment of these frail and elderly patients, who are on the threshold between necessity of chemotherapy for AL amyloidosis and necessity to avoid harmful treatment related toxicity. All patients with a systemic amyloid syndrome require therapy to prevent deposition of amyloid in other organs and prevent progressive organ failure. Stem cell transplant (SCT) is preferred, but only 20% of patients are eligible Requirements for safe SCT include systolic blood pressure >90 mm Hg, troponin T <0.06 ng/mL, age <70 years, and serum creatinine ≤1.7 mg/dL Nontransplant candidates can be offered melphalandexamethasone or cyclophosphamide-bortezomibdexamethasone.
|
topic |
Amyloidosis, plasma cell dyscrasia, electron microscopy, multiple myeloma, rheumatologic disease, cardiovascular disease, renal disease |
url |
https://pagepress.org/journals/index.php/hr/article/view/7996 |
work_keys_str_mv |
AT francescamartini differenttypesofamyloidconcomitantlypresentinthesamepatients AT gabrielebuda differenttypesofamyloidconcomitantlypresentinthesamepatients AT vincenzodetata differenttypesofamyloidconcomitantlypresentinthesamepatients AT saragalimberti differenttypesofamyloidconcomitantlypresentinthesamepatients AT enricoorciuolo differenttypesofamyloidconcomitantlypresentinthesamepatients AT matildemasini differenttypesofamyloidconcomitantlypresentinthesamepatients AT mariopetrini differenttypesofamyloidconcomitantlypresentinthesamepatients |
_version_ |
1724466683607777280 |