Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1

Polycystic kidney disease 2-like 1 protein (PKD2L1) is a voltage-dependent calcium-dependent nonselective ion channel involved in sour taste perception and regulation of pH-dependent action potential of spinal cord neurons. Here the authors present the 3.4 Å cryo-EM structure of PKD2L1 in the open s...

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Main Authors:	Qiang Su, Feizhuo Hu, Yuxia Liu, Xiaofei Ge, Changlin Mei, Shengqiang Yu, Aiwen Shen, Qiang Zhou, Chuangye Yan, Jianlin Lei, Yanqing Zhang, Xiaodong Liu, Tingliang Wang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03606-0

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spelling	doaj-ce9827ec7c7d442e97b9327ed4729e192021-05-11T10:24:23ZengNature Publishing GroupNature Communications2041-17232018-03-019111210.1038/s41467-018-03606-0Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1Qiang Su0Feizhuo Hu1Yuxia Liu2Xiaofei Ge3Changlin Mei4Shengqiang Yu5Aiwen Shen6Qiang Zhou7Chuangye Yan8Jianlin Lei9Yanqing Zhang10Xiaodong Liu11Tingliang Wang12Ministry of Education Key Laboratory of Protein Science, Tsinghua UniversityMinistry of Education Key Laboratory of Protein Science, Tsinghua UniversitySchool of Medicine, Tsinghua UniversityMinistry of Education Key Laboratory of Protein Science, Tsinghua UniversityDepartment of Nephrology, Changzheng Hospital, Second Military Medical UniversityDepartment of Nephrology, Changzheng Hospital, Second Military Medical UniversityDepartment of Nephrology, Changzheng Hospital, Second Military Medical UniversityMinistry of Education Key Laboratory of Protein Science, Tsinghua UniversityMinistry of Education Key Laboratory of Protein Science, Tsinghua UniversityMinistry of Education Key Laboratory of Protein Science, Tsinghua UniversityMinistry of Education Key Laboratory of Protein Science, Tsinghua UniversitySchool of Life Sciences, Tsinghua UniversityMinistry of Education Key Laboratory of Protein Science, Tsinghua UniversityPolycystic kidney disease 2-like 1 protein (PKD2L1) is a voltage-dependent calcium-dependent nonselective ion channel involved in sour taste perception and regulation of pH-dependent action potential of spinal cord neurons. Here the authors present the 3.4 Å cryo-EM structure of PKD2L1 in the open state and propose a model for the gating mechanism.https://doi.org/10.1038/s41467-018-03606-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Qiang Su Feizhuo Hu Yuxia Liu Xiaofei Ge Changlin Mei Shengqiang Yu Aiwen Shen Qiang Zhou Chuangye Yan Jianlin Lei Yanqing Zhang Xiaodong Liu Tingliang Wang
spellingShingle	Qiang Su Feizhuo Hu Yuxia Liu Xiaofei Ge Changlin Mei Shengqiang Yu Aiwen Shen Qiang Zhou Chuangye Yan Jianlin Lei Yanqing Zhang Xiaodong Liu Tingliang Wang Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1 Nature Communications
author_facet	Qiang Su Feizhuo Hu Yuxia Liu Xiaofei Ge Changlin Mei Shengqiang Yu Aiwen Shen Qiang Zhou Chuangye Yan Jianlin Lei Yanqing Zhang Xiaodong Liu Tingliang Wang
author_sort	Qiang Su
title	Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
title_short	Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
title_full	Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
title_fullStr	Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
title_full_unstemmed	Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
title_sort	cryo-em structure of the polycystic kidney disease-like channel pkd2l1
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-03-01
description	Polycystic kidney disease 2-like 1 protein (PKD2L1) is a voltage-dependent calcium-dependent nonselective ion channel involved in sour taste perception and regulation of pH-dependent action potential of spinal cord neurons. Here the authors present the 3.4 Å cryo-EM structure of PKD2L1 in the open state and propose a model for the gating mechanism.
url	https://doi.org/10.1038/s41467-018-03606-0
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Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1

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