IL-37 Gene and Cholesterol Metabolism: Association of Polymorphisms with the Presence of Hypercholesterolemia and Cardiovascular Risk Factors. The GEA Mexican Study
Interleukin 37 (<i>IL-37</i>) is an anti-inflammatory cytokine involved in the regulation of cholesterol homeostasis, reducing the levels of plasma cholesterol, fatty acids, and triglycerides. The aim of the present study was to evaluate the association of the IL-37 polymorphisms with th...
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doaj-ce99874722a94d3983e2f488fd7f4a6e2020-11-25T03:59:17ZengMDPI AGBiomolecules2218-273X2020-10-01101409140910.3390/biom10101409IL-37 Gene and Cholesterol Metabolism: Association of Polymorphisms with the Presence of Hypercholesterolemia and Cardiovascular Risk Factors. The GEA Mexican StudyFabiola López-Bautista0Rosalinda Posadas-Sánchez1Christian Vázquez-Vázquez2José Manuel Fragoso3José Manuel Rodríguez-Pérez4Gilberto Vargas-Alarcón5Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoInterleukin 37 (<i>IL-37</i>) is an anti-inflammatory cytokine involved in the regulation of cholesterol homeostasis, reducing the levels of plasma cholesterol, fatty acids, and triglycerides. The aim of the present study was to evaluate the association of the IL-37 polymorphisms with the presence of hypercholesterolemia (HC), and with cardiovascular risk factors. Nine IL-37 polymorphisms (rs2708965, rs2708962, rs6717710, rs2708961, rs2708960, rs2708958, rs2723187, rs2708947, and rs2723192) were determined by TaqMan assays in a group of 1292 individuals (514 with and 778 without hypercholesterolemia) belonging to the cohort of the GEA Mexican Study. The associations were evaluated by logistic regression, using inheritance models adjusted by confounding variables. Under codominant 1 model, the rs2708961 (OR = 0.51, <i>p</i> = 0.02), rs2723187 (OR = 0.35, <i>p</i> = 0.005), and rs2708947 (OR = 0.49, <i>p</i> = 0.02) polymorphisms were associated with low risk of HC. The association of the polymorphisms with cardiovascular risk factors was evaluated independently in HC and non-HC individuals. In non-HC individuals, some polymorphisms were associated with the risk of having high levels of LDL-C, glucose, and high risk of T2DM, and low risk of having high visceral abdominal fat. On the other hand, in individuals with HC five, polymorphisms were associated with high levels of C-reactive protein. The <i>IL-37</i> rs2708961, rs2723187, rs2708947 polymorphisms were associated with low risk of HC, and some <i>IL-37</i> polymorphisms were associated with cardiometabolic factors in both individuals with and without HC.https://www.mdpi.com/2218-273X/10/10/1409cardiovascular risk factorshypercholesterolemiainflammationinterleukin 37polymorphisms |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fabiola López-Bautista Rosalinda Posadas-Sánchez Christian Vázquez-Vázquez José Manuel Fragoso José Manuel Rodríguez-Pérez Gilberto Vargas-Alarcón |
spellingShingle |
Fabiola López-Bautista Rosalinda Posadas-Sánchez Christian Vázquez-Vázquez José Manuel Fragoso José Manuel Rodríguez-Pérez Gilberto Vargas-Alarcón IL-37 Gene and Cholesterol Metabolism: Association of Polymorphisms with the Presence of Hypercholesterolemia and Cardiovascular Risk Factors. The GEA Mexican Study Biomolecules cardiovascular risk factors hypercholesterolemia inflammation interleukin 37 polymorphisms |
author_facet |
Fabiola López-Bautista Rosalinda Posadas-Sánchez Christian Vázquez-Vázquez José Manuel Fragoso José Manuel Rodríguez-Pérez Gilberto Vargas-Alarcón |
author_sort |
Fabiola López-Bautista |
title |
IL-37 Gene and Cholesterol Metabolism: Association of Polymorphisms with the Presence of Hypercholesterolemia and Cardiovascular Risk Factors. The GEA Mexican Study |
title_short |
IL-37 Gene and Cholesterol Metabolism: Association of Polymorphisms with the Presence of Hypercholesterolemia and Cardiovascular Risk Factors. The GEA Mexican Study |
title_full |
IL-37 Gene and Cholesterol Metabolism: Association of Polymorphisms with the Presence of Hypercholesterolemia and Cardiovascular Risk Factors. The GEA Mexican Study |
title_fullStr |
IL-37 Gene and Cholesterol Metabolism: Association of Polymorphisms with the Presence of Hypercholesterolemia and Cardiovascular Risk Factors. The GEA Mexican Study |
title_full_unstemmed |
IL-37 Gene and Cholesterol Metabolism: Association of Polymorphisms with the Presence of Hypercholesterolemia and Cardiovascular Risk Factors. The GEA Mexican Study |
title_sort |
il-37 gene and cholesterol metabolism: association of polymorphisms with the presence of hypercholesterolemia and cardiovascular risk factors. the gea mexican study |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2020-10-01 |
description |
Interleukin 37 (<i>IL-37</i>) is an anti-inflammatory cytokine involved in the regulation of cholesterol homeostasis, reducing the levels of plasma cholesterol, fatty acids, and triglycerides. The aim of the present study was to evaluate the association of the IL-37 polymorphisms with the presence of hypercholesterolemia (HC), and with cardiovascular risk factors. Nine IL-37 polymorphisms (rs2708965, rs2708962, rs6717710, rs2708961, rs2708960, rs2708958, rs2723187, rs2708947, and rs2723192) were determined by TaqMan assays in a group of 1292 individuals (514 with and 778 without hypercholesterolemia) belonging to the cohort of the GEA Mexican Study. The associations were evaluated by logistic regression, using inheritance models adjusted by confounding variables. Under codominant 1 model, the rs2708961 (OR = 0.51, <i>p</i> = 0.02), rs2723187 (OR = 0.35, <i>p</i> = 0.005), and rs2708947 (OR = 0.49, <i>p</i> = 0.02) polymorphisms were associated with low risk of HC. The association of the polymorphisms with cardiovascular risk factors was evaluated independently in HC and non-HC individuals. In non-HC individuals, some polymorphisms were associated with the risk of having high levels of LDL-C, glucose, and high risk of T2DM, and low risk of having high visceral abdominal fat. On the other hand, in individuals with HC five, polymorphisms were associated with high levels of C-reactive protein. The <i>IL-37</i> rs2708961, rs2723187, rs2708947 polymorphisms were associated with low risk of HC, and some <i>IL-37</i> polymorphisms were associated with cardiometabolic factors in both individuals with and without HC. |
topic |
cardiovascular risk factors hypercholesterolemia inflammation interleukin 37 polymorphisms |
url |
https://www.mdpi.com/2218-273X/10/10/1409 |
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