A case report of septic shock syndrome caused by S. pneumoniae in an immunocompromised patient despite of vaccination
Abstract Background and case presentation We report a case of septic shock syndrome caused by Streptococcus pneumoniae in a patient who had undergone splenectomy due to an autoimmune lymphoproliferative syndrome (ALPS), which is characterized as a dysfunction of immunoregulation. Although the patien...
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doaj-ceaa2efd05424b42897c5d18d26b57052020-11-25T03:23:10ZengBMCBMC Infectious Diseases1471-23342017-06-011711510.1186/s12879-017-2481-yA case report of septic shock syndrome caused by S. pneumoniae in an immunocompromised patient despite of vaccinationJosef Singer0Christoph Testori1Peter Schellongowski2Ammon Handisurya3Catharina Müller4Eva-Maria Reitter5Wolfgang Graninger6Paul Knöbl7Thomas Staudinger8Stefan Winkler9Florian Thalhammer10Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of ViennaDepartment of Emergency Medicine, Medical University of ViennaIntensive Care Unit 13i2, Department of Internal Medicine I, Medical University of ViennaClinical Department for Nephrology and Dialysis, Department of Internal Medicine III, Medical University of ViennaDivision of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of ViennaDivision of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of ViennaDivision of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of ViennaClinical Department of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of ViennaIntensive Care Unit 13i2, Department of Internal Medicine I, Medical University of ViennaDivision of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of ViennaDivision of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of ViennaAbstract Background and case presentation We report a case of septic shock syndrome caused by Streptococcus pneumoniae in a patient who had undergone splenectomy due to an autoimmune lymphoproliferative syndrome (ALPS), which is characterized as a dysfunction of immunoregulation. Although the patient was vaccinated with a conjugated polysaccharide vaccine after the splenectomy, he was still susceptible to S. pneumoniae infection, because the isolated serovar (24F), a serovar long thought to be apathogenic, is not covered by any vaccine currently approved, neither a conjugated nor an unconjugated polysaccharide one. Conclusions This case demonstrates that, due to presence of different serovars, also infections with bacteria against which patients are vaccinated have to be considered as differential diagnosis. Although vaccine development has extended the coverage of S. pneumoniae from 7 to 23 serovars within recent years, there is still demand for novel vaccines which can provide broader protection also against so-thought “apathogenic” strains, especially for groups at high risk.http://link.springer.com/article/10.1186/s12879-017-2481-yCase reportStreptococcus pneumoniae Serovar 24FAutoimmune lymphoproliferative syndrome (ALPS)Overwhelming post-splenectomy infection (OPSI)Vaccination |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Josef Singer Christoph Testori Peter Schellongowski Ammon Handisurya Catharina Müller Eva-Maria Reitter Wolfgang Graninger Paul Knöbl Thomas Staudinger Stefan Winkler Florian Thalhammer |
spellingShingle |
Josef Singer Christoph Testori Peter Schellongowski Ammon Handisurya Catharina Müller Eva-Maria Reitter Wolfgang Graninger Paul Knöbl Thomas Staudinger Stefan Winkler Florian Thalhammer A case report of septic shock syndrome caused by S. pneumoniae in an immunocompromised patient despite of vaccination BMC Infectious Diseases Case report Streptococcus pneumoniae Serovar 24F Autoimmune lymphoproliferative syndrome (ALPS) Overwhelming post-splenectomy infection (OPSI) Vaccination |
author_facet |
Josef Singer Christoph Testori Peter Schellongowski Ammon Handisurya Catharina Müller Eva-Maria Reitter Wolfgang Graninger Paul Knöbl Thomas Staudinger Stefan Winkler Florian Thalhammer |
author_sort |
Josef Singer |
title |
A case report of septic shock syndrome caused by S. pneumoniae in an immunocompromised patient despite of vaccination |
title_short |
A case report of septic shock syndrome caused by S. pneumoniae in an immunocompromised patient despite of vaccination |
title_full |
A case report of septic shock syndrome caused by S. pneumoniae in an immunocompromised patient despite of vaccination |
title_fullStr |
A case report of septic shock syndrome caused by S. pneumoniae in an immunocompromised patient despite of vaccination |
title_full_unstemmed |
A case report of septic shock syndrome caused by S. pneumoniae in an immunocompromised patient despite of vaccination |
title_sort |
case report of septic shock syndrome caused by s. pneumoniae in an immunocompromised patient despite of vaccination |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2017-06-01 |
description |
Abstract Background and case presentation We report a case of septic shock syndrome caused by Streptococcus pneumoniae in a patient who had undergone splenectomy due to an autoimmune lymphoproliferative syndrome (ALPS), which is characterized as a dysfunction of immunoregulation. Although the patient was vaccinated with a conjugated polysaccharide vaccine after the splenectomy, he was still susceptible to S. pneumoniae infection, because the isolated serovar (24F), a serovar long thought to be apathogenic, is not covered by any vaccine currently approved, neither a conjugated nor an unconjugated polysaccharide one. Conclusions This case demonstrates that, due to presence of different serovars, also infections with bacteria against which patients are vaccinated have to be considered as differential diagnosis. Although vaccine development has extended the coverage of S. pneumoniae from 7 to 23 serovars within recent years, there is still demand for novel vaccines which can provide broader protection also against so-thought “apathogenic” strains, especially for groups at high risk. |
topic |
Case report Streptococcus pneumoniae Serovar 24F Autoimmune lymphoproliferative syndrome (ALPS) Overwhelming post-splenectomy infection (OPSI) Vaccination |
url |
http://link.springer.com/article/10.1186/s12879-017-2481-y |
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