Is there an association between labor induction and attention-deficit/hyperactivity disorder among children?

Background There is evidence of destructive effects of oxytocin use during labor on neurodevelopment. Purpose This meta-analysis pooled all observational studies to determine the association between labor induction and the risk of attention-deficit/hyperactivity disorder (ADHD) among children. Metho...

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Main Authors: Ensiyeh Jenabi, Mahdieh Seyedi, Saeid Bashirian, Bita Fereidooni
Format: Article
Language:English
Published: The Korean Pediatric Society 2021-09-01
Series:Clinical and Experimental Pediatrics
Subjects:
Online Access:http://www.e-cep.org/upload/pdf/cep-2020-01557.pdf
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spelling doaj-ceacafc7778443ceb7aa4168163b83f02021-09-02T07:47:44ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482021-09-0164948949310.3345/cep.2020.0155720125555413Is there an association between labor induction and attention-deficit/hyperactivity disorder among children?Ensiyeh Jenabi0Mahdieh Seyedi1Saeid Bashirian2Bita Fereidooni3 Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Midwife in Social Security Organization, Hamadan, IranBackground There is evidence of destructive effects of oxytocin use during labor on neurodevelopment. Purpose This meta-analysis pooled all observational studies to determine the association between labor induction and the risk of attention-deficit/hyperactivity disorder (ADHD) among children. Methods All observational studies (case-control and cohort) were reviewed until September 2020 after searches of the PubMed, Scopus, and Web of Science databases, the gray literature, and conference proceedings. The pooled odds ratios (ORs), relative ratios (RRs), and 95% confidence intervals (CI (swere calculated as random effect estimates of association among studies. Results All observational studies were reviewed, including 4 cohort studies including 2,885,743 participants and 3 case-control studies including 51,135 participants (10,961 with ADHD and 40,174 in control groups) with a sample size of 2,936,878 participants. The pooled estimates of OR and RR did not indicate a significant association between labor induction and ADHD among children (OR, 1.13; 95% CI, 0.90–1.35) and (RR, 1.10; 95% CI, 0.96–1.24). Conclusions The findings showed that labor induction is not associated with an increased risk of ADHD among children. However, more studies are needed to investigate the relationship between labor induction and ADHD.http://www.e-cep.org/upload/pdf/cep-2020-01557.pdfattention deficit disorder with hyperactivitylabor inductionmeta-analysis
collection DOAJ
language English
format Article
sources DOAJ
author Ensiyeh Jenabi
Mahdieh Seyedi
Saeid Bashirian
Bita Fereidooni
spellingShingle Ensiyeh Jenabi
Mahdieh Seyedi
Saeid Bashirian
Bita Fereidooni
Is there an association between labor induction and attention-deficit/hyperactivity disorder among children?
Clinical and Experimental Pediatrics
attention deficit disorder with hyperactivity
labor induction
meta-analysis
author_facet Ensiyeh Jenabi
Mahdieh Seyedi
Saeid Bashirian
Bita Fereidooni
author_sort Ensiyeh Jenabi
title Is there an association between labor induction and attention-deficit/hyperactivity disorder among children?
title_short Is there an association between labor induction and attention-deficit/hyperactivity disorder among children?
title_full Is there an association between labor induction and attention-deficit/hyperactivity disorder among children?
title_fullStr Is there an association between labor induction and attention-deficit/hyperactivity disorder among children?
title_full_unstemmed Is there an association between labor induction and attention-deficit/hyperactivity disorder among children?
title_sort is there an association between labor induction and attention-deficit/hyperactivity disorder among children?
publisher The Korean Pediatric Society
series Clinical and Experimental Pediatrics
issn 2713-4148
publishDate 2021-09-01
description Background There is evidence of destructive effects of oxytocin use during labor on neurodevelopment. Purpose This meta-analysis pooled all observational studies to determine the association between labor induction and the risk of attention-deficit/hyperactivity disorder (ADHD) among children. Methods All observational studies (case-control and cohort) were reviewed until September 2020 after searches of the PubMed, Scopus, and Web of Science databases, the gray literature, and conference proceedings. The pooled odds ratios (ORs), relative ratios (RRs), and 95% confidence intervals (CI (swere calculated as random effect estimates of association among studies. Results All observational studies were reviewed, including 4 cohort studies including 2,885,743 participants and 3 case-control studies including 51,135 participants (10,961 with ADHD and 40,174 in control groups) with a sample size of 2,936,878 participants. The pooled estimates of OR and RR did not indicate a significant association between labor induction and ADHD among children (OR, 1.13; 95% CI, 0.90–1.35) and (RR, 1.10; 95% CI, 0.96–1.24). Conclusions The findings showed that labor induction is not associated with an increased risk of ADHD among children. However, more studies are needed to investigate the relationship between labor induction and ADHD.
topic attention deficit disorder with hyperactivity
labor induction
meta-analysis
url http://www.e-cep.org/upload/pdf/cep-2020-01557.pdf
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