TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration

Group migration of cranial neural crest cells depends upon Eph-ephrin signalling. Here, the authors show that TBC1d24 complexes with ephrinB2 via Dishevelled to induce contact inhibition of locomotion by reducing membrane E-cadherin. Eph receptor binding dissolves this complex and disrupts migration...

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Bibliographic Details
Main Authors: Jaeho Yoon, Yoo-Seok Hwang, Moonsup Lee, Jian Sun, Hee Jun Cho, Laura Knapik, Ira O. Daar
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05924-9

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