Developmental changes in rat brain membrane lipids and fatty acids: the preferential prenatal accumulation of docosahexaenoic acid
Information on the prenatal accumulation of rat brain membrane lipids is scarce. In this study we investigated in detail the fatty acid (FA) composition of the rat brain, on each day from embryonic day 12 (E12) up to birth, and on 8 time points during the first 16 days of postnatal life, and correla...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
1999-05-01
|
Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520321325 |
id |
doaj-ceaf66972b3f450da9048bf4217b626c |
---|---|
record_format |
Article |
spelling |
doaj-ceaf66972b3f450da9048bf4217b626c2021-04-27T04:42:12ZengElsevierJournal of Lipid Research0022-22751999-05-01405960966Developmental changes in rat brain membrane lipids and fatty acids: the preferential prenatal accumulation of docosahexaenoic acidPnina Green0Sabina Glozman1Batya Kamensky2Ephraim Yavin3Department of Internal Medicine B, The Rabin Medical Center (Beilinson Campus), Petah Tikva and the Sackler School of Medicine, Tel-Aviv University, 76100 Rehovot, Israel; Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, IsraelDepartment of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, IsraelDepartment of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, IsraelTo whom correspondence should be addressed.; Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, IsraelInformation on the prenatal accumulation of rat brain membrane lipids is scarce. In this study we investigated in detail the fatty acid (FA) composition of the rat brain, on each day from embryonic day 12 (E12) up to birth, and on 8 time points during the first 16 days of postnatal life, and correlated the FA changes with well-described events of neurogenesis and synaptogenesis. Between E14 and E17, there was a steep increase in the concentration of all the FAs: 16:0 increased by 136%, 18:0 by 139%, 18:1 by 92%, 20:4n–6 by 98%, 22:4n–6 by 116%, 22:5n–6 by 220%, and 22:6n–3 by 98%. After this period and up to birth, the concentration of the FAs plateaued, except that of 22:6n–3, which accumulated further, reaching an additional increase of 75%. After birth, except 22:5n–6, all FAs steadily increased at various rates. Estimation of the FA/PL molar ratios showed that prenatally the ratios of all the FAs either decreased or remained constant, but that of 22:6n–3 increased more than 2-fold; postnatally the ratios remained constant, with the exception of 22:4n–6 and 22:5n–6, which decreased. In conclusion, prenatal accumulation of brain fatty acids parallels important events in neurogenesis. 22:6n–3 is exceptional inasmuch in its steep accumulation occurs just prior to synaptogenesis.—Green, P., S. Glozman, B. Kamensky, and E. Yavin. Developmental chantes in rat brain membrane lipids and fatty acids: the preferential prenatal accumulation of docosahexaenoic acid. J. Lipid Res. 1999. 40: 960–966.http://www.sciencedirect.com/science/article/pii/S0022227520321325brain developmentpolyunsaturated fatty acidsessential fatty acidsphospholipids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pnina Green Sabina Glozman Batya Kamensky Ephraim Yavin |
spellingShingle |
Pnina Green Sabina Glozman Batya Kamensky Ephraim Yavin Developmental changes in rat brain membrane lipids and fatty acids: the preferential prenatal accumulation of docosahexaenoic acid Journal of Lipid Research brain development polyunsaturated fatty acids essential fatty acids phospholipids |
author_facet |
Pnina Green Sabina Glozman Batya Kamensky Ephraim Yavin |
author_sort |
Pnina Green |
title |
Developmental changes in rat brain membrane lipids and fatty acids: the preferential prenatal accumulation of docosahexaenoic acid |
title_short |
Developmental changes in rat brain membrane lipids and fatty acids: the preferential prenatal accumulation of docosahexaenoic acid |
title_full |
Developmental changes in rat brain membrane lipids and fatty acids: the preferential prenatal accumulation of docosahexaenoic acid |
title_fullStr |
Developmental changes in rat brain membrane lipids and fatty acids: the preferential prenatal accumulation of docosahexaenoic acid |
title_full_unstemmed |
Developmental changes in rat brain membrane lipids and fatty acids: the preferential prenatal accumulation of docosahexaenoic acid |
title_sort |
developmental changes in rat brain membrane lipids and fatty acids: the preferential prenatal accumulation of docosahexaenoic acid |
publisher |
Elsevier |
series |
Journal of Lipid Research |
issn |
0022-2275 |
publishDate |
1999-05-01 |
description |
Information on the prenatal accumulation of rat brain membrane lipids is scarce. In this study we investigated in detail the fatty acid (FA) composition of the rat brain, on each day from embryonic day 12 (E12) up to birth, and on 8 time points during the first 16 days of postnatal life, and correlated the FA changes with well-described events of neurogenesis and synaptogenesis. Between E14 and E17, there was a steep increase in the concentration of all the FAs: 16:0 increased by 136%, 18:0 by 139%, 18:1 by 92%, 20:4n–6 by 98%, 22:4n–6 by 116%, 22:5n–6 by 220%, and 22:6n–3 by 98%. After this period and up to birth, the concentration of the FAs plateaued, except that of 22:6n–3, which accumulated further, reaching an additional increase of 75%. After birth, except 22:5n–6, all FAs steadily increased at various rates. Estimation of the FA/PL molar ratios showed that prenatally the ratios of all the FAs either decreased or remained constant, but that of 22:6n–3 increased more than 2-fold; postnatally the ratios remained constant, with the exception of 22:4n–6 and 22:5n–6, which decreased. In conclusion, prenatal accumulation of brain fatty acids parallels important events in neurogenesis. 22:6n–3 is exceptional inasmuch in its steep accumulation occurs just prior to synaptogenesis.—Green, P., S. Glozman, B. Kamensky, and E. Yavin. Developmental chantes in rat brain membrane lipids and fatty acids: the preferential prenatal accumulation of docosahexaenoic acid. J. Lipid Res. 1999. 40: 960–966. |
topic |
brain development polyunsaturated fatty acids essential fatty acids phospholipids |
url |
http://www.sciencedirect.com/science/article/pii/S0022227520321325 |
work_keys_str_mv |
AT pninagreen developmentalchangesinratbrainmembranelipidsandfattyacidsthepreferentialprenatalaccumulationofdocosahexaenoicacid AT sabinaglozman developmentalchangesinratbrainmembranelipidsandfattyacidsthepreferentialprenatalaccumulationofdocosahexaenoicacid AT batyakamensky developmentalchangesinratbrainmembranelipidsandfattyacidsthepreferentialprenatalaccumulationofdocosahexaenoicacid AT ephraimyavin developmentalchangesinratbrainmembranelipidsandfattyacidsthepreferentialprenatalaccumulationofdocosahexaenoicacid |
_version_ |
1721506842242187264 |