Pharmacomicrobiomics: a novel route towards personalized medicine?
ABSTRACT Inter-individual heterogeneity in drug response is a serious problem that affects the patient’s wellbeing and poses enormous clinical and financial burdens on a societal level. Pharmacogenomics has been at the forefront of research into the impact of individual genetic background on drug re...
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doaj-ceb2c5a4c6374b26a674bc1c4f0587e72020-11-24T22:00:02ZengSpringerOpenProtein & Cell1674-800X1674-80182018-04-019543244510.1007/s13238-018-0547-2Pharmacomicrobiomics: a novel route towards personalized medicine?Marwah Doestzada0Arnau Vich Vila1Alexandra Zhernakova2Debby P. Y. Koonen3Rinse K. Weersma4Daan J. Touw5Folkert Kuipers6Cisca Wijmenga7Jingyuan Fu8Departments of Genetics, University Medical Center GroningenDepartments of Genetics, University Medical Center GroningenDepartments of Genetics, University Medical Center GroningenDepartments of Paediatrics, University Medical Center GroningenDepartments of Gastroenterology & Hepatology, University Medical Center GroningenDepartments of Clinical Pharmacy & Pharmacology, University Medical Center GroningenDepartments of Paediatrics, University Medical Center GroningenDepartments of Genetics, University Medical Center GroningenDepartments of Genetics, University Medical Center GroningenABSTRACT Inter-individual heterogeneity in drug response is a serious problem that affects the patient’s wellbeing and poses enormous clinical and financial burdens on a societal level. Pharmacogenomics has been at the forefront of research into the impact of individual genetic background on drug response variability or drug toxicity, and recently the gut microbiome, which has also been called the second genome, has been recognized as an important player in this respect. Moreover, the microbiome is a very attractive target for improving drug efficacy and safety due to the opportunities to manipulate its composition. Pharmacomicrobiomics is an emerging field that investigates the interplay of microbiome variation and drugs response and disposition (absorption, distribution, metabolism and excretion). In this review, we provide a historical overview and examine current state-of-the-art knowledge on the complex interactions between gut microbiome, host and drugs. We argue that combining pharmacogenomics and pharmacomicrobiomics will provide an important foundation for making major advances in personalized medicine.http://link.springer.com/article/10.1007/s13238-018-0547-2gut microbiomedrug metabolismpersonalized medicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marwah Doestzada Arnau Vich Vila Alexandra Zhernakova Debby P. Y. Koonen Rinse K. Weersma Daan J. Touw Folkert Kuipers Cisca Wijmenga Jingyuan Fu |
spellingShingle |
Marwah Doestzada Arnau Vich Vila Alexandra Zhernakova Debby P. Y. Koonen Rinse K. Weersma Daan J. Touw Folkert Kuipers Cisca Wijmenga Jingyuan Fu Pharmacomicrobiomics: a novel route towards personalized medicine? Protein & Cell gut microbiome drug metabolism personalized medicine |
author_facet |
Marwah Doestzada Arnau Vich Vila Alexandra Zhernakova Debby P. Y. Koonen Rinse K. Weersma Daan J. Touw Folkert Kuipers Cisca Wijmenga Jingyuan Fu |
author_sort |
Marwah Doestzada |
title |
Pharmacomicrobiomics: a novel route towards personalized medicine? |
title_short |
Pharmacomicrobiomics: a novel route towards personalized medicine? |
title_full |
Pharmacomicrobiomics: a novel route towards personalized medicine? |
title_fullStr |
Pharmacomicrobiomics: a novel route towards personalized medicine? |
title_full_unstemmed |
Pharmacomicrobiomics: a novel route towards personalized medicine? |
title_sort |
pharmacomicrobiomics: a novel route towards personalized medicine? |
publisher |
SpringerOpen |
series |
Protein & Cell |
issn |
1674-800X 1674-8018 |
publishDate |
2018-04-01 |
description |
ABSTRACT Inter-individual heterogeneity in drug response is a serious problem that affects the patient’s wellbeing and poses enormous clinical and financial burdens on a societal level. Pharmacogenomics has been at the forefront of research into the impact of individual genetic background on drug response variability or drug toxicity, and recently the gut microbiome, which has also been called the second genome, has been recognized as an important player in this respect. Moreover, the microbiome is a very attractive target for improving drug efficacy and safety due to the opportunities to manipulate its composition. Pharmacomicrobiomics is an emerging field that investigates the interplay of microbiome variation and drugs response and disposition (absorption, distribution, metabolism and excretion). In this review, we provide a historical overview and examine current state-of-the-art knowledge on the complex interactions between gut microbiome, host and drugs. We argue that combining pharmacogenomics and pharmacomicrobiomics will provide an important foundation for making major advances in personalized medicine. |
topic |
gut microbiome drug metabolism personalized medicine |
url |
http://link.springer.com/article/10.1007/s13238-018-0547-2 |
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