Risk Factors of Multiple Gastric Polyps according to the Histologic Classification: Prospective Observational Cohort Study
Background/Aims: The aim of this study was to determine the risk factors of multiple gastric polyps according to the histological classification of gastric polyps. Methods: Subjects with multiple gastric polyps (at least three) during endoscopy were enrolled prospectively. They were assigned to a f...
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doaj-ceb594afc72a4f8f9b97ccd7467137b02020-11-25T01:18:26ZengJin Publishing & Printing Co.The Korean Journal of Gastroenterology1598-99922233-68692019-07-01741172910.4166/kjg.2019.74.1.17Risk Factors of Multiple Gastric Polyps according to the Histologic Classification: Prospective Observational Cohort StudyChan Young Jeong0Nayoung Kim1Hye Seung Lee2Hyuk Yoon3Cheol Min Shin4Young Soo Park5Jin-Wook Kim6Dong Ho Lee7Departments of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Korea Departments of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, KoreaDepartments of Pathology, Seoul National University Bundang Hospital, Seoungnam, KoreaDepartments of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Korea Departments of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Korea Departments of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Korea Departments of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, KoreaDepartments of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, KoreaBackground/Aims: The aim of this study was to determine the risk factors of multiple gastric polyps according to the histological classification of gastric polyps. Methods: Subjects with multiple gastric polyps (at least three) during endoscopy were enrolled prospectively. They were assigned to a fundic gland polyp (FGP) group and hyperplastic polyp (HP) group based on a histological classification of gastric polyps. Helicobacter pylori (H. pylori) was confirmed by its histology. Serum gastrin was measured using the radioimmunoassay method. A questionnaire was taken regarding the intake of proton pump inhibitor and nonsteroidal anti-inflammatory drugs, alcohol, smoking history, and diet. Results: Among the 60 subjects enrolled from 2015 to 2018 at Seoul National University Bungdang Hospital, 47 and 13 subjects were assigned to the FGP and HP groups, respectively. The H. pylori infection rate was 12.8% in the FGP group, which is lower than that in the HP group (69.2%, p<0.001). The gastrin level was higher in the HP group (194.7 pg/dL, range 50.6-387.8 pg/dL) than in the FGP group (57.4 pg/dL, range 24.8-79.0 pg/dL) (p=0.007). Histologically, neutrophil infiltration in the antrum and body of the stomach were higher in the HP group than in the FGP group (p=0.022 and p=0.030, respectively). In contrast, monocyte infiltration in the antrum and body of the stomach were higher in the FGP group than in the HP group (p=0.018 and p<0.001, respectively). Conclusions: HPs arise from inflammation caused by H. pylori. On the other hand, the FGP was not associated with H. pylori or environmental factors.http://www.kjg.or.kr/journal/view.html?uid=5472&vmd=Full&Gastric polypsHelicobacter pyloriProton pump inhibitorsGastrin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chan Young Jeong Nayoung Kim Hye Seung Lee Hyuk Yoon Cheol Min Shin Young Soo Park Jin-Wook Kim Dong Ho Lee |
spellingShingle |
Chan Young Jeong Nayoung Kim Hye Seung Lee Hyuk Yoon Cheol Min Shin Young Soo Park Jin-Wook Kim Dong Ho Lee Risk Factors of Multiple Gastric Polyps according to the Histologic Classification: Prospective Observational Cohort Study The Korean Journal of Gastroenterology Gastric polyps Helicobacter pylori Proton pump inhibitors Gastrin |
author_facet |
Chan Young Jeong Nayoung Kim Hye Seung Lee Hyuk Yoon Cheol Min Shin Young Soo Park Jin-Wook Kim Dong Ho Lee |
author_sort |
Chan Young Jeong |
title |
Risk Factors of Multiple Gastric Polyps according to the Histologic Classification: Prospective Observational Cohort Study |
title_short |
Risk Factors of Multiple Gastric Polyps according to the Histologic Classification: Prospective Observational Cohort Study |
title_full |
Risk Factors of Multiple Gastric Polyps according to the Histologic Classification: Prospective Observational Cohort Study |
title_fullStr |
Risk Factors of Multiple Gastric Polyps according to the Histologic Classification: Prospective Observational Cohort Study |
title_full_unstemmed |
Risk Factors of Multiple Gastric Polyps according to the Histologic Classification: Prospective Observational Cohort Study |
title_sort |
risk factors of multiple gastric polyps according to the histologic classification: prospective observational cohort study |
publisher |
Jin Publishing & Printing Co. |
series |
The Korean Journal of Gastroenterology |
issn |
1598-9992 2233-6869 |
publishDate |
2019-07-01 |
description |
Background/Aims: The aim of this study was to determine the risk factors of multiple gastric polyps according to the histological classification of gastric polyps.
Methods: Subjects with multiple gastric polyps (at least three) during endoscopy were enrolled prospectively. They were assigned to a fundic gland polyp (FGP) group and hyperplastic polyp (HP) group based on a histological classification of gastric polyps. Helicobacter pylori (H. pylori) was confirmed by its histology. Serum gastrin was measured using the radioimmunoassay method. A questionnaire was taken regarding the intake of proton pump inhibitor and nonsteroidal anti-inflammatory drugs, alcohol, smoking history, and diet.
Results: Among the 60 subjects enrolled from 2015 to 2018 at Seoul National University Bungdang Hospital, 47 and 13 subjects
were assigned to the FGP and HP groups, respectively. The H. pylori infection rate was 12.8% in the FGP group, which is lower than that in the HP group (69.2%, p<0.001). The gastrin level was higher in the HP group (194.7 pg/dL, range 50.6-387.8 pg/dL) than
in the FGP group (57.4 pg/dL, range 24.8-79.0 pg/dL) (p=0.007). Histologically, neutrophil infiltration in the antrum and body of the
stomach were higher in the HP group than in the FGP group (p=0.022 and p=0.030, respectively). In contrast, monocyte infiltration in the antrum and body of the stomach were higher in the FGP group than in the HP group (p=0.018 and p<0.001, respectively).
Conclusions: HPs arise from inflammation caused by H. pylori. On the other hand, the FGP was not associated with H. pylori or environmental factors. |
topic |
Gastric polyps Helicobacter pylori Proton pump inhibitors Gastrin |
url |
http://www.kjg.or.kr/journal/view.html?uid=5472&vmd=Full& |
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