Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function
Cognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes to cell-mediated immunity in creating an oxidative environment. Food is a vitally important energy source; it affects brain function and provides direct energy. Several studies have indicated that high-fat cons...
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doaj-cebd8a3db08b433fbc4f09c7a0bf7f912020-11-24T21:19:13ZengMDPI AGNutrients2072-66432019-10-011111257910.3390/nu11112579nu11112579Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive FunctionBee Ling Tan0Mohd Esa Norhaizan1Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, MalaysiaDepartment of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, MalaysiaCognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes to cell-mediated immunity in creating an oxidative environment. Food is a vitally important energy source; it affects brain function and provides direct energy. Several studies have indicated that high-fat consumption causes overproduction of circulating free fatty acids and systemic inflammation. Immune cells, free fatty acids, and circulating cytokines reach the hypothalamus and initiate local inflammation through processes such as microglial proliferation. Therefore, the role of high-fat diet (HFD) in promoting oxidative stress and neurodegeneration is worthy of further discussion. Of particular interest in this article, we highlight the associations and molecular mechanisms of HFD in the modulation of inflammation and cognitive deficits. Taken together, a better understanding of the role of oxidative stress in cognitive impairment following HFD consumption would provide a useful approach for the prevention of cognitive dysfunction.https://www.mdpi.com/2072-6643/11/11/2579cognitive impairmenthigh-fat dietinflammationneurodegenerationoxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bee Ling Tan Mohd Esa Norhaizan |
spellingShingle |
Bee Ling Tan Mohd Esa Norhaizan Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function Nutrients cognitive impairment high-fat diet inflammation neurodegeneration oxidative stress |
author_facet |
Bee Ling Tan Mohd Esa Norhaizan |
author_sort |
Bee Ling Tan |
title |
Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function |
title_short |
Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function |
title_full |
Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function |
title_fullStr |
Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function |
title_full_unstemmed |
Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function |
title_sort |
effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-10-01 |
description |
Cognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes to cell-mediated immunity in creating an oxidative environment. Food is a vitally important energy source; it affects brain function and provides direct energy. Several studies have indicated that high-fat consumption causes overproduction of circulating free fatty acids and systemic inflammation. Immune cells, free fatty acids, and circulating cytokines reach the hypothalamus and initiate local inflammation through processes such as microglial proliferation. Therefore, the role of high-fat diet (HFD) in promoting oxidative stress and neurodegeneration is worthy of further discussion. Of particular interest in this article, we highlight the associations and molecular mechanisms of HFD in the modulation of inflammation and cognitive deficits. Taken together, a better understanding of the role of oxidative stress in cognitive impairment following HFD consumption would provide a useful approach for the prevention of cognitive dysfunction. |
topic |
cognitive impairment high-fat diet inflammation neurodegeneration oxidative stress |
url |
https://www.mdpi.com/2072-6643/11/11/2579 |
work_keys_str_mv |
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