The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data
Background/AimsLiver stiffness measurement (LSM) has been proposed as a non-invasive method for estimating the severity of fibrosis and the complications of cirrhosis. Measurement of the hepatic venous pressure gradient (HVPG) is the gold standard for assessing the presence of portal hypertension, b...
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Korean Association for the Study of the Liver
2013-12-01
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Series: | Clinical and Molecular Hepatology |
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Online Access: | http://e-cmh.org/upload/pdf/cmh-19-370.pdf |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Won Ki Hong Moon Young Kim Soon Koo Baik Seung Yong Shin Jung Min Kim Yong Seok Kang Yoo Li Lim Young Ju Kim Youn Zoo Cho Hye Won Hwang Jin Hyung Lee Myeong Hun Chae Hyoun A Kim Hye Won Kang Sang Ok Kwon |
spellingShingle |
Won Ki Hong Moon Young Kim Soon Koo Baik Seung Yong Shin Jung Min Kim Yong Seok Kang Yoo Li Lim Young Ju Kim Youn Zoo Cho Hye Won Hwang Jin Hyung Lee Myeong Hun Chae Hyoun A Kim Hye Won Kang Sang Ok Kwon The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data Clinical and Molecular Hepatology Portal hypertension Liver stiffness measurement Cirrhosis |
author_facet |
Won Ki Hong Moon Young Kim Soon Koo Baik Seung Yong Shin Jung Min Kim Yong Seok Kang Yoo Li Lim Young Ju Kim Youn Zoo Cho Hye Won Hwang Jin Hyung Lee Myeong Hun Chae Hyoun A Kim Hye Won Kang Sang Ok Kwon |
author_sort |
Won Ki Hong |
title |
The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data |
title_short |
The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data |
title_full |
The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data |
title_fullStr |
The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data |
title_full_unstemmed |
The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data |
title_sort |
usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: korean data |
publisher |
Korean Association for the Study of the Liver |
series |
Clinical and Molecular Hepatology |
issn |
2287-2728 2287-285X |
publishDate |
2013-12-01 |
description |
Background/AimsLiver stiffness measurement (LSM) has been proposed as a non-invasive method for estimating the severity of fibrosis and the complications of cirrhosis. Measurement of the hepatic venous pressure gradient (HVPG) is the gold standard for assessing the presence of portal hypertension, but its invasiveness limits its clinical application. In this study we evaluated the relationship between LSM and HVPG, and the predictive value of LSM for clinically significant portal hypertension (CSPH) and severe portal hypertension in cirrhosis.MethodsLSM was performed with transient elastography in 59 consecutive cirrhotic patients who underwent hemodynamic HVPG investigations. CSPH and severe portal hypertension were defined as HVPG ≥10 and ≥12 mmHg, respectively. Linear regression analysis was performed to evaluate the relationship between LSM and HVPG. Diagnostic values were analyzed based on receiver operating characteristic (ROC) curves.ResultsA strong positive correlation between LSM and HVPG was observed in the overall population (r2=0.496, P<0.0001). The area under the ROC curve (AUROC) for the prediction of CSPH (HVPG ≥10 mmHg) was 0.851, and the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for an LSM cutoff value of 21.95 kPa were 82.5%, 73.7%, 86.8%, and 66.7%, respectively. The AUROC at prediction of severe portal hypertension (HVPG ≥12 mmHg) was 0.877, and the sensitivity, specificity, PPV, and NPV at LSM cutoff value of 24.25 kPa were 82.9%, 70.8%, 80.6%, and 73.9%, respectively.ConclusionsLSM exhibited a significant correlation with HVPG in patients with cirrhosis. LSM could be a non-invasive method for predicting CSPH and severe portal hypertension in Korean patients with liver cirrhosis. |
topic |
Portal hypertension Liver stiffness measurement Cirrhosis |
url |
http://e-cmh.org/upload/pdf/cmh-19-370.pdf |
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doaj-cec3deb553674aa5b50bdd933b26044e2020-11-24T21:22:50ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2013-12-0119437037510.3350/cmh.2013.19.4.3701049The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean dataWon Ki Hong0Moon Young Kim1Soon Koo Baik2Seung Yong Shin3Jung Min Kim4Yong Seok Kang5Yoo Li Lim6Young Ju Kim7Youn Zoo Cho8Hye Won Hwang9Jin Hyung Lee10Myeong Hun Chae11Hyoun A Kim12Hye Won Kang13Sang Ok Kwon14Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Korea.Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Korea.Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Korea.Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Korea.Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Korea.Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Korea.Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Korea.Department of Radiology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Korea.Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Korea.Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Korea.Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Korea.Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Korea.Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Korea.Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Korea.Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Korea.Background/AimsLiver stiffness measurement (LSM) has been proposed as a non-invasive method for estimating the severity of fibrosis and the complications of cirrhosis. Measurement of the hepatic venous pressure gradient (HVPG) is the gold standard for assessing the presence of portal hypertension, but its invasiveness limits its clinical application. In this study we evaluated the relationship between LSM and HVPG, and the predictive value of LSM for clinically significant portal hypertension (CSPH) and severe portal hypertension in cirrhosis.MethodsLSM was performed with transient elastography in 59 consecutive cirrhotic patients who underwent hemodynamic HVPG investigations. CSPH and severe portal hypertension were defined as HVPG ≥10 and ≥12 mmHg, respectively. Linear regression analysis was performed to evaluate the relationship between LSM and HVPG. Diagnostic values were analyzed based on receiver operating characteristic (ROC) curves.ResultsA strong positive correlation between LSM and HVPG was observed in the overall population (r2=0.496, P<0.0001). The area under the ROC curve (AUROC) for the prediction of CSPH (HVPG ≥10 mmHg) was 0.851, and the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for an LSM cutoff value of 21.95 kPa were 82.5%, 73.7%, 86.8%, and 66.7%, respectively. The AUROC at prediction of severe portal hypertension (HVPG ≥12 mmHg) was 0.877, and the sensitivity, specificity, PPV, and NPV at LSM cutoff value of 24.25 kPa were 82.9%, 70.8%, 80.6%, and 73.9%, respectively.ConclusionsLSM exhibited a significant correlation with HVPG in patients with cirrhosis. LSM could be a non-invasive method for predicting CSPH and severe portal hypertension in Korean patients with liver cirrhosis.http://e-cmh.org/upload/pdf/cmh-19-370.pdfPortal hypertensionLiver stiffness measurementCirrhosis |