Reduced eIF3d accelerates HIV disease progression by attenuating CD8+ T cell function

Reduced eIF3d accelerates HIV disease progression by attenuating CD8+ T cell function

Abstract Background In human immunodeficiency virus (HIV) infection, 10–15% of individuals exhibit a rapid decline in CD4+ T cells and become rapid progressors (RPs). Overall, understanding the factors affecting rapid disease progression in early HIV infection (EHI) can aid in treatment initiation....

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Bibliographic Details
Main Authors: Ying Pan, Zi-Ning Zhang, Lin-Bo Yin, Ya-Jing Fu, Yong-Jun Jiang, Hong Shang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Translational Medicine
Subjects:
HIV
Rapid progressors
CD8+ T cells
eIF3d
Proliferation
IFN-γ
Online Access:http://link.springer.com/article/10.1186/s12967-019-1925-0

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