MiR-29c inhibits cell growth, invasion, and migration of pancreatic cancer by targeting ITGB1

• Main Authors: Lu Y, Hu JJ, Sun W, Li S, Deng S, Li M
• Format: Article
• Language: English
• Published: Dove Medical Press 2015-12-01
• Series: OncoTargets and Therapy
• Subjects: miR-29c; pancreatic cancer; cell growth; cell migration; cell invasion; integrin β1 (ITGB1)
• Online Access: https://www.dovepress.com/mir-29c-inhibits-cell-growth-invasion-and-migration-of-pancreatic-canc-peer-reviewed-article-OTT

Yebin Lu, Juanjuan Hu, Weijia Sun, Shengyu Li, Shuangya Deng, Ming Li Department of General Surgery, Xiangya Hospital, Central South University, Changsha, People’s Republic of China Abstract: MiR-29c is frequently dysregulated in many cancers; however, the roles of miR-29c in pancreatic cancer (PC) and underlying mechanisms remain poorly understood. In this study, we investigated the role of miR-29c in PC. Using quantitative real-time polymerase chain reaction, we demonstrated that miR-29c was frequently downregulated in clinical PC tissues and cell lines. Overexpression of miR-29c significantly inhibited the proliferation, migration, and invasion of PC cells in vitro, which demonstrated that miR-29c acts as a tumor suppressor in PC cells. Further analysis revealed that ITGB1 is one of the functional target genes of miR-29c, and knockdown of ITGB1 inhibited the proliferation, migration, and invasion of PC cells, which was similar to the effects of overexpression of miR-29c. Taken together, our results highlight the significance of miR-29c–ITGB1 interaction in the development and progression of PC. Keywords: miR-29c, tumor suppressor, pancreatic cancer, ITGB1