Alpha 2-antiplasmin deficiency in a Sudanese child: a case report
Abstract Background The plasma serine protease inhibitor alpha 2-antiplasmin (α2-AP, otherwise known as α2-plasmin inhibitor) is a rapid-acting plasmin inhibitor recently found in human plasma, which seems to have a significant role in the regulation of in vivo fibrinolysis. Congenital deficiency of...
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doaj-cedede2994b44842a56c6058abdc71372021-05-09T11:16:50ZengBMCJournal of Medical Case Reports1752-19472021-05-011511510.1186/s13256-021-02813-6Alpha 2-antiplasmin deficiency in a Sudanese child: a case reportBashir Abdrhman Bashir Mohammed0Hematology Department, Faculty of Medical Laboratory Sciences, Port Sudan Ahlia CollegeAbstract Background The plasma serine protease inhibitor alpha 2-antiplasmin (α2-AP, otherwise known as α2-plasmin inhibitor) is a rapid-acting plasmin inhibitor recently found in human plasma, which seems to have a significant role in the regulation of in vivo fibrinolysis. Congenital deficiency of α2-AP is extremely uncommon. Case presentation We report here a case of absolute deficiency of α2-AP in an 11-year-old Sudanese boy, who had a lifelong intermittent hemorrhagic tendency (gum bleeding, epistaxis, and exaggerated bleeding after trauma). Coagulation tests including prothrombin time, partial thromboplastin time, thrombin time, bleeding time, platelet count, clot retraction test, antithrombin, and factor VIII levels were within normal limits. Hepatic function tests and complete blood count were also normal. The main interesting finding in this patient was that the whole blood clot lysis was extremely fast, completed within 5–8 hours. The second abnormal finding is that the euglobulin clot lysis time was short. Nevertheless, the concentration of α2-AP in the patient's plasma was 0.2 IU/ml (reference range is 0.80–1.20 IU/ml). The addition of pooled plasma (with normal α2-AP) to the patient's whole blood corrected the accelerated fibrinolysis. Conclusion The study showed that α2-AP deficiency resulted in uninhibited fibrinolysis that caused the hemorrhagic tendency in this patient. Thus, this report demonstrates the significant role of α2-AP in coagulation.https://doi.org/10.1186/s13256-021-02813-6Alpha 2-antiplasmin (α2-AP)FibrinolysisBleeding tendencySudan |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bashir Abdrhman Bashir Mohammed |
spellingShingle |
Bashir Abdrhman Bashir Mohammed Alpha 2-antiplasmin deficiency in a Sudanese child: a case report Journal of Medical Case Reports Alpha 2-antiplasmin (α2-AP) Fibrinolysis Bleeding tendency Sudan |
author_facet |
Bashir Abdrhman Bashir Mohammed |
author_sort |
Bashir Abdrhman Bashir Mohammed |
title |
Alpha 2-antiplasmin deficiency in a Sudanese child: a case report |
title_short |
Alpha 2-antiplasmin deficiency in a Sudanese child: a case report |
title_full |
Alpha 2-antiplasmin deficiency in a Sudanese child: a case report |
title_fullStr |
Alpha 2-antiplasmin deficiency in a Sudanese child: a case report |
title_full_unstemmed |
Alpha 2-antiplasmin deficiency in a Sudanese child: a case report |
title_sort |
alpha 2-antiplasmin deficiency in a sudanese child: a case report |
publisher |
BMC |
series |
Journal of Medical Case Reports |
issn |
1752-1947 |
publishDate |
2021-05-01 |
description |
Abstract Background The plasma serine protease inhibitor alpha 2-antiplasmin (α2-AP, otherwise known as α2-plasmin inhibitor) is a rapid-acting plasmin inhibitor recently found in human plasma, which seems to have a significant role in the regulation of in vivo fibrinolysis. Congenital deficiency of α2-AP is extremely uncommon. Case presentation We report here a case of absolute deficiency of α2-AP in an 11-year-old Sudanese boy, who had a lifelong intermittent hemorrhagic tendency (gum bleeding, epistaxis, and exaggerated bleeding after trauma). Coagulation tests including prothrombin time, partial thromboplastin time, thrombin time, bleeding time, platelet count, clot retraction test, antithrombin, and factor VIII levels were within normal limits. Hepatic function tests and complete blood count were also normal. The main interesting finding in this patient was that the whole blood clot lysis was extremely fast, completed within 5–8 hours. The second abnormal finding is that the euglobulin clot lysis time was short. Nevertheless, the concentration of α2-AP in the patient's plasma was 0.2 IU/ml (reference range is 0.80–1.20 IU/ml). The addition of pooled plasma (with normal α2-AP) to the patient's whole blood corrected the accelerated fibrinolysis. Conclusion The study showed that α2-AP deficiency resulted in uninhibited fibrinolysis that caused the hemorrhagic tendency in this patient. Thus, this report demonstrates the significant role of α2-AP in coagulation. |
topic |
Alpha 2-antiplasmin (α2-AP) Fibrinolysis Bleeding tendency Sudan |
url |
https://doi.org/10.1186/s13256-021-02813-6 |
work_keys_str_mv |
AT bashirabdrhmanbashirmohammed alpha2antiplasmindeficiencyinasudanesechildacasereport |
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