The Wingate anaerobic test cannot be used for the evaluation of growth hormone secretion in children with short stature
Purpose: To assess the growth hormone (GH) response to the Wingate anaerobic test (WAnT) among children with short stature and suspected GH deficiency. We hypothesized that the GH response to the WAnT would be similar to the GH response to a commonly used pharmacologic provocation test. Methods: Ten...
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doaj-cefae51ff35a4922aeab6ad0204f92d22020-11-24T21:29:08ZengElsevierJournal of Sport and Health Science2095-25462017-12-016444344610.1016/j.jshs.2016.06.002The Wingate anaerobic test cannot be used for the evaluation of growth hormone secretion in children with short statureNitzan DrorLiat OrenMichal PantanowitzAlon EliakimDan NemetPurpose: To assess the growth hormone (GH) response to the Wingate anaerobic test (WAnT) among children with short stature and suspected GH deficiency. We hypothesized that the GH response to the WAnT would be similar to the GH response to a commonly used pharmacologic provocation test. Methods: Ten children (6 males and 4 females, age range 9.0–14.9 years) participated in the study. Each participant performed 2 tests: a standard all-out WAnT, cycling for 30 s against constant resistance, and a standardized pharmacologic test (clonidine or glucagon). Blood samples for GH were collected before and 10, 30, 45, and 60 min after the beginning of exercise. In addition, we collected pre- and post-exercise blood lactate levels. Results: There was a significant increase in GH levels after the WAnT, yet in 9 of 10 participants, this increase was below the threshold for GH sufficiency. Peak GH after the WAnT was significantly lower compared to the pharmacologic GH provocation tests (with 9 of 10 demonstrating GH-sufficient response). Conclusion: The traditional WAnT cannot be used as a GH provocation test. Further research is needed to develop anaerobic exercise protocols sufficient to promote GH secretion.http://www.sciencedirect.com/science/article/pii/S2095254616300412AnaerobicExerciseGrowth hormoneLactateProvocation testShort stature |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nitzan Dror Liat Oren Michal Pantanowitz Alon Eliakim Dan Nemet |
spellingShingle |
Nitzan Dror Liat Oren Michal Pantanowitz Alon Eliakim Dan Nemet The Wingate anaerobic test cannot be used for the evaluation of growth hormone secretion in children with short stature Journal of Sport and Health Science Anaerobic Exercise Growth hormone Lactate Provocation test Short stature |
author_facet |
Nitzan Dror Liat Oren Michal Pantanowitz Alon Eliakim Dan Nemet |
author_sort |
Nitzan Dror |
title |
The Wingate anaerobic test cannot be used for the evaluation of growth hormone secretion in children with short stature |
title_short |
The Wingate anaerobic test cannot be used for the evaluation of growth hormone secretion in children with short stature |
title_full |
The Wingate anaerobic test cannot be used for the evaluation of growth hormone secretion in children with short stature |
title_fullStr |
The Wingate anaerobic test cannot be used for the evaluation of growth hormone secretion in children with short stature |
title_full_unstemmed |
The Wingate anaerobic test cannot be used for the evaluation of growth hormone secretion in children with short stature |
title_sort |
wingate anaerobic test cannot be used for the evaluation of growth hormone secretion in children with short stature |
publisher |
Elsevier |
series |
Journal of Sport and Health Science |
issn |
2095-2546 |
publishDate |
2017-12-01 |
description |
Purpose: To assess the growth hormone (GH) response to the Wingate anaerobic test (WAnT) among children with short stature and suspected GH deficiency. We hypothesized that the GH response to the WAnT would be similar to the GH response to a commonly used pharmacologic provocation test.
Methods: Ten children (6 males and 4 females, age range 9.0–14.9 years) participated in the study. Each participant performed 2 tests: a standard all-out WAnT, cycling for 30 s against constant resistance, and a standardized pharmacologic test (clonidine or glucagon). Blood samples for GH were collected before and 10, 30, 45, and 60 min after the beginning of exercise. In addition, we collected pre- and post-exercise blood lactate levels.
Results: There was a significant increase in GH levels after the WAnT, yet in 9 of 10 participants, this increase was below the threshold for GH sufficiency. Peak GH after the WAnT was significantly lower compared to the pharmacologic GH provocation tests (with 9 of 10 demonstrating GH-sufficient response).
Conclusion: The traditional WAnT cannot be used as a GH provocation test. Further research is needed to develop anaerobic exercise protocols sufficient to promote GH secretion. |
topic |
Anaerobic Exercise Growth hormone Lactate Provocation test Short stature |
url |
http://www.sciencedirect.com/science/article/pii/S2095254616300412 |
work_keys_str_mv |
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