Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin
Induction of non-specific toxicities by doxorubicin (DOX) has restricted conventional DOX-based chemotherapy. pH-responsive dextrin nanogels (DNGs) have been fabricated in order to incorporate and deliver DOX to specific (targeted) sites. However, adequate stability studies of DOX-loaded DNGs are re...
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doaj-cf086e338cba4d7aaf81e70869ff62f52020-11-24T23:47:57ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762016-10-0111564865410.1016/j.ajps.2015.09.006Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicinSomkamol Manchun0Crispin R. Dass1Pornsak Sriamornsak2Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandSchool of Pharmacy, Faculty of Health Sciences, Curtin University, Perth 6845, AustraliaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandInduction of non-specific toxicities by doxorubicin (DOX) has restricted conventional DOX-based chemotherapy. pH-responsive dextrin nanogels (DNGs) have been fabricated in order to incorporate and deliver DOX to specific (targeted) sites. However, adequate stability studies of DOX-loaded DNGs are required for selection of storage conditions. The aim of this study was therefore to evaluate the accelerated (25 °C/60% RH) and long-term (5 °C) stability of DNGs prepared with formaldehyde (FDNGs) and glyoxal (GDNGs) as cross-linker by determining the change in their physicochemical properties. The mean diameter decreased with time during long-term storage. The drug content between freshly prepared (initial day) and after storage at 5 °C for 180 days of DOX-loaded FDNGs and DOX-loaded GDNGs was not significantly different (p > 0.05), but decreased after storage under the accelerated condition. The release of DOX from all DNGs was pH-dependent. However, DNGs kept under the accelerated condition showed higher amount of DOX release than those stored at 5 °C and the freshly prepared ones. The results indicate that the stability of DNGs could be improved by their storage at 5 °C.http://www.sciencedirect.com/science/article/pii/S1818087615000914StabilityNanogelsDextrin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Somkamol Manchun Crispin R. Dass Pornsak Sriamornsak |
spellingShingle |
Somkamol Manchun Crispin R. Dass Pornsak Sriamornsak Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin Asian Journal of Pharmaceutical Sciences Stability Nanogels Dextrin |
author_facet |
Somkamol Manchun Crispin R. Dass Pornsak Sriamornsak |
author_sort |
Somkamol Manchun |
title |
Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin |
title_short |
Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin |
title_full |
Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin |
title_fullStr |
Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin |
title_full_unstemmed |
Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin |
title_sort |
stability of freeze-dried ph-responsive dextrin nanogels containing doxorubicin |
publisher |
Elsevier |
series |
Asian Journal of Pharmaceutical Sciences |
issn |
1818-0876 |
publishDate |
2016-10-01 |
description |
Induction of non-specific toxicities by doxorubicin (DOX) has restricted conventional DOX-based chemotherapy. pH-responsive dextrin nanogels (DNGs) have been fabricated in order to incorporate and deliver DOX to specific (targeted) sites. However, adequate stability studies of DOX-loaded DNGs are required for selection of storage conditions. The aim of this study was therefore to evaluate the accelerated (25 °C/60% RH) and long-term (5 °C) stability of DNGs prepared with formaldehyde (FDNGs) and glyoxal (GDNGs) as cross-linker by determining the change in their physicochemical properties. The mean diameter decreased with time during long-term storage. The drug content between freshly prepared (initial day) and after storage at 5 °C for 180 days of DOX-loaded FDNGs and DOX-loaded GDNGs was not significantly different (p > 0.05), but decreased after storage under the accelerated condition. The release of DOX from all DNGs was pH-dependent. However, DNGs kept under the accelerated condition showed higher amount of DOX release than those stored at 5 °C and the freshly prepared ones. The results indicate that the stability of DNGs could be improved by their storage at 5 °C. |
topic |
Stability Nanogels Dextrin |
url |
http://www.sciencedirect.com/science/article/pii/S1818087615000914 |
work_keys_str_mv |
AT somkamolmanchun stabilityoffreezedriedphresponsivedextrinnanogelscontainingdoxorubicin AT crispinrdass stabilityoffreezedriedphresponsivedextrinnanogelscontainingdoxorubicin AT pornsaksriamornsak stabilityoffreezedriedphresponsivedextrinnanogelscontainingdoxorubicin |
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1725487951344828416 |