Comparison of the Reverse-Remodeling Effect of Pharmacological Soluble Guanylate Cyclase Activation With Pressure Unloading in Pathological Myocardial Left Ventricular Hypertrophy

Comparison of the Reverse-Remodeling Effect of Pharmacological Soluble Guanylate Cyclase Activation With Pressure Unloading in Pathological Myocardial Left Ventricular Hypertrophy

Background: Pressure unloading induces the regression of left ventricular myocardial hypertrophy (LVH). Recent findings indicate that pharmacological activation of the soluble guanylate cyclase (sGC) – cyclic guanosine monophosphate (cGMP) pathway may also exert reverse-remodeling properties in the...

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Main Authors: Mihály Ruppert, Sevil Korkmaz-Icöz, Shiliang Li, Paige Brlecic, Balázs Tamás Németh, Attila Oláh, Eszter M. Horváth, Gábor Veres, Sven Pleger, Niels Grabe, Béla Merkely, Matthias Karck, Tamás Radovits, Gábor Szabó
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Physiology
Subjects:
left ventricular hypertrophy
pressure unloading
reverse remodeling
cinaciguat
cGMP
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01869/full

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