Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy

Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy

While nanocarrier-based drug delivery is a promising therapeutic approach, in situ characterization of drug nanocarriers in blood remains difficult. Here, the authors demonstrate how the fluorescence correlation spectroscopy can be used to directly characterize drug nanocarriers in flowing blood.

Bibliographic Details
Main Authors: Inka Negwer, Andreas Best, Meike Schinnerer, Olga Schäfer, Leon Capeloa, Manfred Wagner, Manfred Schmidt, Volker Mailänder, Mark Helm, Matthias Barz, Hans-Jürgen Butt, Kaloian Koynov
Format: Article
Language:English
Published: Nature Publishing Group 2018-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07755-0
id doaj-cf29261ca73b441fab35b8f08719a659
record_format Article
spelling doaj-cf29261ca73b441fab35b8f08719a6592021-05-11T09:45:10ZengNature Publishing GroupNature Communications2041-17232018-12-01911910.1038/s41467-018-07755-0Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopyInka Negwer0Andreas Best1Meike Schinnerer2Olga Schäfer3Leon Capeloa4Manfred Wagner5Manfred Schmidt6Volker Mailänder7Mark Helm8Matthias Barz9Hans-Jürgen Butt10Kaloian Koynov11Max Planck Institute for Polymer ResearchMax Planck Institute for Polymer ResearchInstitute of Physical Chemistry, Johannes Gutenberg UniversityInstitute of Organic Chemistry, Johannes Gutenberg UniversityInstitute of Organic Chemistry, Johannes Gutenberg UniversityMax Planck Institute for Polymer ResearchInstitute of Physical Chemistry, Johannes Gutenberg UniversityMax Planck Institute for Polymer ResearchPharmaceutical Chemistry, Institute of Pharmacy and Biochemistry, Johannes Gutenberg UniversityInstitute of Organic Chemistry, Johannes Gutenberg UniversityMax Planck Institute for Polymer ResearchMax Planck Institute for Polymer ResearchWhile nanocarrier-based drug delivery is a promising therapeutic approach, in situ characterization of drug nanocarriers in blood remains difficult. Here, the authors demonstrate how the fluorescence correlation spectroscopy can be used to directly characterize drug nanocarriers in flowing blood.https://doi.org/10.1038/s41467-018-07755-0
collection DOAJ
language English
format Article
sources DOAJ
author Inka Negwer
Andreas Best
Meike Schinnerer
Olga Schäfer
Leon Capeloa
Manfred Wagner
Manfred Schmidt
Volker Mailänder
Mark Helm
Matthias Barz
Hans-Jürgen Butt
Kaloian Koynov
spellingShingle Inka Negwer
Andreas Best
Meike Schinnerer
Olga Schäfer
Leon Capeloa
Manfred Wagner
Manfred Schmidt
Volker Mailänder
Mark Helm
Matthias Barz
Hans-Jürgen Butt
Kaloian Koynov
Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy
Nature Communications
author_facet Inka Negwer
Andreas Best
Meike Schinnerer
Olga Schäfer
Leon Capeloa
Manfred Wagner
Manfred Schmidt
Volker Mailänder
Mark Helm
Matthias Barz
Hans-Jürgen Butt
Kaloian Koynov
author_sort Inka Negwer
title Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy
title_short Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy
title_full Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy
title_fullStr Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy
title_full_unstemmed Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy
title_sort monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-12-01
description While nanocarrier-based drug delivery is a promising therapeutic approach, in situ characterization of drug nanocarriers in blood remains difficult. Here, the authors demonstrate how the fluorescence correlation spectroscopy can be used to directly characterize drug nanocarriers in flowing blood.
url https://doi.org/10.1038/s41467-018-07755-0
work_keys_str_mv AT inkanegwer monitoringdrugnanocarriersinhumanbloodbynearinfraredfluorescencecorrelationspectroscopy
AT andreasbest monitoringdrugnanocarriersinhumanbloodbynearinfraredfluorescencecorrelationspectroscopy
AT meikeschinnerer monitoringdrugnanocarriersinhumanbloodbynearinfraredfluorescencecorrelationspectroscopy
AT olgaschafer monitoringdrugnanocarriersinhumanbloodbynearinfraredfluorescencecorrelationspectroscopy
AT leoncapeloa monitoringdrugnanocarriersinhumanbloodbynearinfraredfluorescencecorrelationspectroscopy
AT manfredwagner monitoringdrugnanocarriersinhumanbloodbynearinfraredfluorescencecorrelationspectroscopy
AT manfredschmidt monitoringdrugnanocarriersinhumanbloodbynearinfraredfluorescencecorrelationspectroscopy
AT volkermailander monitoringdrugnanocarriersinhumanbloodbynearinfraredfluorescencecorrelationspectroscopy
AT markhelm monitoringdrugnanocarriersinhumanbloodbynearinfraredfluorescencecorrelationspectroscopy
AT matthiasbarz monitoringdrugnanocarriersinhumanbloodbynearinfraredfluorescencecorrelationspectroscopy
AT hansjurgenbutt monitoringdrugnanocarriersinhumanbloodbynearinfraredfluorescencecorrelationspectroscopy
AT kaloiankoynov monitoringdrugnanocarriersinhumanbloodbynearinfraredfluorescencecorrelationspectroscopy
_version_ 1721449335932059648

Similar Items