Structural and functional properties of Grb2 SH2 dimer in CD28 binding
Growth factor receptor-bound protein 2 (Grb2) is an adaptor protein that plays a critical role in cellular signal transduction. It contains a central Src homology 2 (SH2) domain flanked by two Src homology 3 (SH3) domains. Binding of Grb2 SH2 to the cytoplasmic region of CD28, phosphorylated Tyr (pY...
Main Authors: | Yuhi Hosoe, Nobutaka Numoto, Satomi Inaba, Shuhei Ogawa, Hisayuki Morii, Ryo Abe, Nobutoshi Ito, Masayuki Oda |
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Format: | Article |
Language: | English |
Published: |
The Biophysical Society of Japan
2019-02-01
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Series: | Biophysics and Physicobiology |
Subjects: | |
Online Access: | https://doi.org/10.2142/biophysico.16.0_80 |
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