Synthesis, Characterization and Biological Evaluation of Some New Heterocyclic Compounds Derived from 2-Naphthol
The present study deals with the synthesis, spectroscopic characterization, antibacterial and antifungal activities of novel series five-membered ring heterocyclic compounds containing nitrogen and sulfur heteroatoms. The synthetic routes have been divided into two parts: The first one includes synt...
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Salahaddin University-Erbil
2020-06-01
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doaj-cf31c582ed414c7bb1712c97dd9780402020-11-25T03:33:47ZengSalahaddin University-ErbilZanco Journal of Pure and Applied Sciences2218-02302412-39862020-06-0132310.21271/ZJPAS.32.3.12Synthesis, Characterization and Biological Evaluation of Some New Heterocyclic Compounds Derived from 2-NaphtholTrifa Khalaf Mohammed0Media Noori Abdullah1Rostam Rasul Braiem2Chamchamal Technical institute/ Sulaimani Polytechnic University, IraqDepartment of Chemistry, College of Science, Salahaddin University-Erbil, Kurdistan Region, IraqDepartment of Chemistry, College of Science, Salahaddin University-Erbil, Kurdistan Region, IraqThe present study deals with the synthesis, spectroscopic characterization, antibacterial and antifungal activities of novel series five-membered ring heterocyclic compounds containing nitrogen and sulfur heteroatoms. The synthetic routes have been divided into two parts: The first one includes synthesis of compounds (4a-c) through one pot operation three component reaction of 2-naphthol (1), substituted benzaldehyde (2a-c) and thiourea (3) in 1,2-dichloromethane, using a catalytic amount of ZrOCl2.8H2O and compound (6) was synthesized using semicarbazide (5) in absolute ethanol and indium (III) chloride as catalyst. The second part is the hetero-cyclization reactions of the compounds (4a-c and 6) to obtain the heterocyclic compounds (7a-c, 8, and 9). The structures of the synthesized products are verified on the basis of (FT-IR, 1H-NMR and 13C-NMR) spectroscopy. The synthesized compounds antibacterial activities were screened against Staphylococcus aureus (Gram positive) and Escherichia coli (Gram negative) bacteria as compared to standard amikacin and antifungal activity against Candida albicans fungi as compared to standard Nystatin, well diffusion method is used. The antibacterial and antifungal activities of synthesized compounds (7a-c, 8 and 9) were higher than the antibacterial and antifungal activities of synthesized compounds (4a-c and 6).https://zancojournals.su.edu.krd/index.php/JPAS/article/view/3343three component reactionheterocyclic compoundthiazolethiazolidin-4-one12-dihydro-3h-124-triazol-3-one |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Trifa Khalaf Mohammed Media Noori Abdullah Rostam Rasul Braiem |
spellingShingle |
Trifa Khalaf Mohammed Media Noori Abdullah Rostam Rasul Braiem Synthesis, Characterization and Biological Evaluation of Some New Heterocyclic Compounds Derived from 2-Naphthol Zanco Journal of Pure and Applied Sciences three component reaction heterocyclic compound thiazole thiazolidin-4-one 1 2-dihydro-3h-1 2 4-triazol-3-one |
author_facet |
Trifa Khalaf Mohammed Media Noori Abdullah Rostam Rasul Braiem |
author_sort |
Trifa Khalaf Mohammed |
title |
Synthesis, Characterization and Biological Evaluation of Some New Heterocyclic Compounds Derived from 2-Naphthol |
title_short |
Synthesis, Characterization and Biological Evaluation of Some New Heterocyclic Compounds Derived from 2-Naphthol |
title_full |
Synthesis, Characterization and Biological Evaluation of Some New Heterocyclic Compounds Derived from 2-Naphthol |
title_fullStr |
Synthesis, Characterization and Biological Evaluation of Some New Heterocyclic Compounds Derived from 2-Naphthol |
title_full_unstemmed |
Synthesis, Characterization and Biological Evaluation of Some New Heterocyclic Compounds Derived from 2-Naphthol |
title_sort |
synthesis, characterization and biological evaluation of some new heterocyclic compounds derived from 2-naphthol |
publisher |
Salahaddin University-Erbil |
series |
Zanco Journal of Pure and Applied Sciences |
issn |
2218-0230 2412-3986 |
publishDate |
2020-06-01 |
description |
The present study deals with the synthesis, spectroscopic characterization, antibacterial and antifungal activities of novel series five-membered ring heterocyclic compounds containing nitrogen and sulfur heteroatoms. The synthetic routes have been divided into two parts: The first one includes synthesis of compounds (4a-c) through one pot operation three component reaction of 2-naphthol (1), substituted benzaldehyde (2a-c) and thiourea (3) in 1,2-dichloromethane, using a catalytic amount of ZrOCl2.8H2O and compound (6) was synthesized using semicarbazide (5) in absolute ethanol and indium (III) chloride as catalyst. The second part is the hetero-cyclization reactions of the compounds (4a-c and 6) to obtain the heterocyclic compounds (7a-c, 8, and 9). The structures of the synthesized products are verified on the basis of (FT-IR, 1H-NMR and 13C-NMR) spectroscopy. The synthesized compounds antibacterial activities were screened against Staphylococcus aureus (Gram positive) and Escherichia coli (Gram negative) bacteria as compared to standard amikacin and antifungal activity against Candida albicans fungi as compared to standard Nystatin, well diffusion method is used. The antibacterial and antifungal activities of synthesized compounds (7a-c, 8 and 9) were higher than the antibacterial and antifungal activities of synthesized compounds (4a-c and 6). |
topic |
three component reaction heterocyclic compound thiazole thiazolidin-4-one 1 2-dihydro-3h-1 2 4-triazol-3-one |
url |
https://zancojournals.su.edu.krd/index.php/JPAS/article/view/3343 |
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