Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer

Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer

Pancreatic cancer (PC), one of the most lethal solid tumors in humans, has a five-year survival rate of only 4%. Surgical treatment is the only accepted therapy with curative intent because the vast majority of these tumors are chemoresistant. Unfortunately, due to the aggressive nature of these tum...

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Bibliographic Details
Main Authors: Andreea Nedelcu, Teodora Mocan, Cristiana Grapa, Lucian Mocan
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
pancreatic cancer
drug delivery
nanoparticles
Online Access:https://www.mdpi.com/1422-0067/22/15/8060
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spelling doaj-cf37cb6b11df4944a97b6c5d1b6728d82021-08-06T15:25:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-01228060806010.3390/ijms22158060Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic CancerAndreea Nedelcu0Teodora Mocan1Cristiana Grapa2Lucian Mocan33rd Surgery Clinic, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400158 Cluj-Napoca, RomaniaNanomedicine Department, Regional Institute of Gastroenterology and Hepatology, Octavian Fodor, 400158 Cluj-Napoca, RomaniaNanomedicine Department, Regional Institute of Gastroenterology and Hepatology, Octavian Fodor, 400158 Cluj-Napoca, Romania3rd Surgery Clinic, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400158 Cluj-Napoca, RomaniaPancreatic cancer (PC), one of the most lethal solid tumors in humans, has a five-year survival rate of only 4%. Surgical treatment is the only accepted therapy with curative intent because the vast majority of these tumors are chemoresistant. Unfortunately, due to the aggressive nature of these tumors, fewer than 20% are resectable when the first symptoms occur. Novel therapies are required to overcome all these therapeutic issues, and the development of active nanocarriers represents an exciting opportunity to improve PC outcomes. The present review focuses on recent advances in the field of nanotechnology with application in PC treatment.https://www.mdpi.com/1422-0067/22/15/8060pancreatic cancerdrug deliverynanoparticles
collection DOAJ
language English
format Article
sources DOAJ
author Andreea Nedelcu
Teodora Mocan
Cristiana Grapa
Lucian Mocan
spellingShingle Andreea Nedelcu
Teodora Mocan
Cristiana Grapa
Lucian Mocan
Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer
International Journal of Molecular Sciences
pancreatic cancer
drug delivery
nanoparticles
author_facet Andreea Nedelcu
Teodora Mocan
Cristiana Grapa
Lucian Mocan
author_sort Andreea Nedelcu
title Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer
title_short Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer
title_full Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer
title_fullStr Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer
title_full_unstemmed Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer
title_sort recent advances in nanoparticle-mediated diagnosis and the treatment of pancreatic cancer
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-07-01
description Pancreatic cancer (PC), one of the most lethal solid tumors in humans, has a five-year survival rate of only 4%. Surgical treatment is the only accepted therapy with curative intent because the vast majority of these tumors are chemoresistant. Unfortunately, due to the aggressive nature of these tumors, fewer than 20% are resectable when the first symptoms occur. Novel therapies are required to overcome all these therapeutic issues, and the development of active nanocarriers represents an exciting opportunity to improve PC outcomes. The present review focuses on recent advances in the field of nanotechnology with application in PC treatment.
topic pancreatic cancer
drug delivery
nanoparticles
url https://www.mdpi.com/1422-0067/22/15/8060
work_keys_str_mv AT andreeanedelcu recentadvancesinnanoparticlemediateddiagnosisandthetreatmentofpancreaticcancer
AT teodoramocan recentadvancesinnanoparticlemediateddiagnosisandthetreatmentofpancreaticcancer
AT cristianagrapa recentadvancesinnanoparticlemediateddiagnosisandthetreatmentofpancreaticcancer
AT lucianmocan recentadvancesinnanoparticlemediateddiagnosisandthetreatmentofpancreaticcancer
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