Insight into skin cell-based osteogenesis: a review [version 1; referees: 2 approved]
For decades, researchers have been fascinated by the strategy of using cell therapy for bone defects; some progress in the field has been made. Owing to its ample supply and easy access, skin, the largest organ in the body, has gained attention as a potential source of stem cells. Despite extensive...
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doaj-cf40c5fa2aa8478ba6939b33f2c0b87d2020-11-25T03:43:48ZengF1000 Research LtdF1000Research2046-14022017-03-01610.12688/f1000research.10280.111072Insight into skin cell-based osteogenesis: a review [version 1; referees: 2 approved]Tingliang Wang0Lian Zhu1Ming Pei2Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMary Babb Randolph Cancer Center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USAFor decades, researchers have been fascinated by the strategy of using cell therapy for bone defects; some progress in the field has been made. Owing to its ample supply and easy access, skin, the largest organ in the body, has gained attention as a potential source of stem cells. Despite extensive applications in skin and nerve regeneration, an increasing number of reports indicate its potential use in bone tissue engineering and regeneration. Unfortunately, few review articles are available to outline current research efforts in skin-based osteogenesis. This review first summarizes the latest findings on stem cells or progenitors in skin and their niches and then discusses the strategies of skin cell-based osteogenesis. We hope this article elucidates this topic and generates new ideas for future studies.https://f1000research.com/articles/6-291/v1Developmental Molecular MechanismsMedical GeneticsMorphogenesis & Cell BiologyMuscle & Connective TissueMusculoskeletal Repair & RegenerationStem Cells & Regeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tingliang Wang Lian Zhu Ming Pei |
spellingShingle |
Tingliang Wang Lian Zhu Ming Pei Insight into skin cell-based osteogenesis: a review [version 1; referees: 2 approved] F1000Research Developmental Molecular Mechanisms Medical Genetics Morphogenesis & Cell Biology Muscle & Connective Tissue Musculoskeletal Repair & Regeneration Stem Cells & Regeneration |
author_facet |
Tingliang Wang Lian Zhu Ming Pei |
author_sort |
Tingliang Wang |
title |
Insight into skin cell-based osteogenesis: a review [version 1; referees: 2 approved] |
title_short |
Insight into skin cell-based osteogenesis: a review [version 1; referees: 2 approved] |
title_full |
Insight into skin cell-based osteogenesis: a review [version 1; referees: 2 approved] |
title_fullStr |
Insight into skin cell-based osteogenesis: a review [version 1; referees: 2 approved] |
title_full_unstemmed |
Insight into skin cell-based osteogenesis: a review [version 1; referees: 2 approved] |
title_sort |
insight into skin cell-based osteogenesis: a review [version 1; referees: 2 approved] |
publisher |
F1000 Research Ltd |
series |
F1000Research |
issn |
2046-1402 |
publishDate |
2017-03-01 |
description |
For decades, researchers have been fascinated by the strategy of using cell therapy for bone defects; some progress in the field has been made. Owing to its ample supply and easy access, skin, the largest organ in the body, has gained attention as a potential source of stem cells. Despite extensive applications in skin and nerve regeneration, an increasing number of reports indicate its potential use in bone tissue engineering and regeneration. Unfortunately, few review articles are available to outline current research efforts in skin-based osteogenesis. This review first summarizes the latest findings on stem cells or progenitors in skin and their niches and then discusses the strategies of skin cell-based osteogenesis. We hope this article elucidates this topic and generates new ideas for future studies. |
topic |
Developmental Molecular Mechanisms Medical Genetics Morphogenesis & Cell Biology Muscle & Connective Tissue Musculoskeletal Repair & Regeneration Stem Cells & Regeneration |
url |
https://f1000research.com/articles/6-291/v1 |
work_keys_str_mv |
AT tingliangwang insightintoskincellbasedosteogenesisareviewversion1referees2approved AT lianzhu insightintoskincellbasedosteogenesisareviewversion1referees2approved AT mingpei insightintoskincellbasedosteogenesisareviewversion1referees2approved |
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1724518223469084672 |