QT interval prolongation after sertraline overdose: a case report
<p>Abstract</p> <p>Background</p> <p>Selective serotonin reuptake inhibitors (SSRIs) are the most common antidepressants used in first-world countries and are generally well tolerated. Specifically, less cardiovascular toxicity has been reported in comparison with tricy...
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doaj-cf46c07bde08434a8b616d2aaf5101eb2020-11-24T21:14:32ZengBMCBMC Emergency Medicine1471-227X2005-07-0151510.1186/1471-227X-5-5QT interval prolongation after sertraline overdose: a case reportHolman Nicole Dvan Dijk Tonnis Hde Boer Rudolf Avan Melle Joost P<p>Abstract</p> <p>Background</p> <p>Selective serotonin reuptake inhibitors (SSRIs) are the most common antidepressants used in first-world countries and are generally well tolerated. Specifically, less cardiovascular toxicity has been reported in comparison with tricyclic antidepressants. Here we report QT interval prolongation after an overdose of the SSRI sertraline.</p> <p>Case presentation</p> <p>A previously healthy female patient presented with an attempted suicide with overdoses sertraline (2250 mg), diazepam (200 mg), and temazepam (400 mg). Routine laboratory studies were normal and her ECG upon admission showed a normal QT interval. The next day, her ECG showed prolongation of the QT<sub>c </sub>interval up to 525 ms. After discontinuation of sertraline the QT interval normalized. Echocardiography and exercise electrocardiography were normal. After hospitalization, the patient resumed sertraline in the normally recommended dose and QT interval remained within normal ranges.</p> <p>Conclusion</p> <p>It seems that the SSRI sertraline in overdose may cause QT interval prolongation.</p> http://www.biomedcentral.com/1471-227X/5/5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Holman Nicole D van Dijk Tonnis H de Boer Rudolf A van Melle Joost P |
spellingShingle |
Holman Nicole D van Dijk Tonnis H de Boer Rudolf A van Melle Joost P QT interval prolongation after sertraline overdose: a case report BMC Emergency Medicine |
author_facet |
Holman Nicole D van Dijk Tonnis H de Boer Rudolf A van Melle Joost P |
author_sort |
Holman Nicole D |
title |
QT interval prolongation after sertraline overdose: a case report |
title_short |
QT interval prolongation after sertraline overdose: a case report |
title_full |
QT interval prolongation after sertraline overdose: a case report |
title_fullStr |
QT interval prolongation after sertraline overdose: a case report |
title_full_unstemmed |
QT interval prolongation after sertraline overdose: a case report |
title_sort |
qt interval prolongation after sertraline overdose: a case report |
publisher |
BMC |
series |
BMC Emergency Medicine |
issn |
1471-227X |
publishDate |
2005-07-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Selective serotonin reuptake inhibitors (SSRIs) are the most common antidepressants used in first-world countries and are generally well tolerated. Specifically, less cardiovascular toxicity has been reported in comparison with tricyclic antidepressants. Here we report QT interval prolongation after an overdose of the SSRI sertraline.</p> <p>Case presentation</p> <p>A previously healthy female patient presented with an attempted suicide with overdoses sertraline (2250 mg), diazepam (200 mg), and temazepam (400 mg). Routine laboratory studies were normal and her ECG upon admission showed a normal QT interval. The next day, her ECG showed prolongation of the QT<sub>c </sub>interval up to 525 ms. After discontinuation of sertraline the QT interval normalized. Echocardiography and exercise electrocardiography were normal. After hospitalization, the patient resumed sertraline in the normally recommended dose and QT interval remained within normal ranges.</p> <p>Conclusion</p> <p>It seems that the SSRI sertraline in overdose may cause QT interval prolongation.</p> |
url |
http://www.biomedcentral.com/1471-227X/5/5 |
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