Upregulation of PD-1 expression on circulating CD8+ but not CD4+ T cells is associated with tuberculosis infection in health care workers

Upregulation of PD-1 expression on circulating CD8+ but not CD4+ T cells is associated with tuberculosis infection in health care workers

Abstract Background Health care workers (HCWs) are at risk for occupationally acquired Mycobacterium tuberculosis infection and tuberculosis (TB) disease due to repeated exposure to workplace tubercle bacilli. To determine whether continual mycobacterial stimulation correlates with increased express...

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Bibliographic Details
Main Authors: Cui-lin Shi, Jian-ping Zhang, Ping Xu, Jin Li, Jie Shen, Mei-ying Wu, Zhi-jian Ye, Xin Yu, Hua-feng Song, Hui Chen, Jun-chi Xu, Yu Pang, Jian-an Huang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Immunology
Subjects:
Health care worker
Latent tuberculosis infection
PD-1
Immunodepletion
T cell
Online Access:https://doi.org/10.1186/s12865-021-00433-9

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