Acute pancreatitis and vasoplegic shock associated with leptospirosis – a case report and review of the literature

• Main Authors: Alexander Maier, Rafael Kaeser, Robert Thimme, Tobias Boettler
• Format: Article
• Language: English
• Published: BMC 2019-05-01
• Series: BMC Infectious Diseases
• Subjects: Leptospirosis; Pancreatitis; Septic shock; Europe; Case report
• Online Access: http://link.springer.com/article/10.1186/s12879-019-4040-1

Abstract Background Leptospirosis or Weil’s disease is caused by pathogenic spirochete bacteria called Leptospira. It is considered the most common zoonosis in the world and is usually transmitted by urine of rodents and dogs with an incubation time of 7–14 days. The clinical spectrum ranges from a subclinical infection to a fulminant septic course. Case presentation Here, we report the case of a German patient with acute pancreatitis associated with Leptospira interrogans causing fulminant septic shock. The patient was successfully treated with intravenous antibiotics and left the hospital fully recovered after 18 days. Conclusions To our knowledge, this is the first case of leptospirosis with acute pancreatitis as the leading clinical manifestation in Central Europe. Serologic and molecular genetic tests for leptospirosis should be considered, if no other causes for pancreatitis can be identified.