HCV and HBV prevalence based on home blood self-sampling and screening history in the general population in 2016: contribution to the new French screening strategy
Abstract Background The advent of effective direct-acting antivirals (DAAs), has prompted an assessment of the French Hepatitis C virus (HCV) screening strategy, which historically targeted high-risk groups. One of the options put forward is the implementation of combined (i.e., simultaneous) HCV, H...
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doaj-cf4ff64075c64c04b3c96d32fd39f3062020-11-25T04:04:10ZengBMCBMC Infectious Diseases1471-23342019-10-0119111410.1186/s12879-019-4493-2HCV and HBV prevalence based on home blood self-sampling and screening history in the general population in 2016: contribution to the new French screening strategyCécile Brouard0Leïla Saboni1Arnaud Gautier2Stéphane Chevaliez3Delphine Rahib4Jean-Baptiste Richard5Francis Barin6Christine Larsen7Cécile Sommen8Josiane Pillonel9Elisabeth Delarocque-Astagneau10Nathalie Lydié11Florence Lot12the 2016 Health Barometer GroupSanté publique France, the national public health agency, HIV, Hepatitis B/C and STI UnitSanté publique France, the national public health agency, HIV, Hepatitis B/C and STI UnitSanté publique France, the national public health agency, Surveys UnitNational Reference Centre for Viral Hepatitis B, C and Delta, Department of Virology, Henri Mondor University HospitalSanté publique France, the national public health agency, Sexual Health UnitSanté publique France, the national public health agency, Surveys UnitNational Reference Centre for HIV, Department of Virology, Bretonneau University HospitalSanté publique France, the national public health agency, Sexual Health UnitSanté publique France, the national public health agency, Biostatistics UnitSanté publique France, the national public health agency, HIV, Hepatitis B/C and STI UnitINSERM 1181, Biostatistics, Biomathematics, Pharmacoepidemiology, and Infectious Diseases (B2PHI)Santé publique France, the national public health agency, Sexual Health UnitSanté publique France, the national public health agency, HIV, Hepatitis B/C and STI UnitAbstract Background The advent of effective direct-acting antivirals (DAAs), has prompted an assessment of the French Hepatitis C virus (HCV) screening strategy, which historically targeted high-risk groups. One of the options put forward is the implementation of combined (i.e., simultaneous) HCV, Hepatitis B virus (HBV) and HIV screening for all adults at least once during their lifetime (“universal combined screening”). However, recent national survey-based data are lacking to guide decision-making regarding which new strategy to implement. Accordingly, we aimed to provide updated data for both chronic hepatitis C (CHC) and B (CHB) prevalence and for HCV and HBV screening history, using data from the BaroTest and 2016 Health Barometer (2016-HB) studies, respectively. Methods 2016-HB was a national cross-sectional phone based health survey conducted in 2016 among 20,032 randomly selected individuals from the general population in mainland France. BaroTest was a virological sub-study nested in 2016-HB. Data collected for BaroTest were based on home blood self-sampling on dried blood spots (DBS). Results From 6945 analyzed DBS, chronic hepatitis C (CHC) and B (CHB) prevalence was estimated at 0.30% (95% Confidence Interval (CI): 0.13-0.70) and 0.30% (95% CI: 0.13-0.70), respectively. The proportion of individuals aware of their status was estimated at 80.6% (95% CI: 44.2-95.6) for CHC and 17.5% (95% CI: 4.9-46.4) for CHB. Universal combined screening would involve testing between 32.6 and 85.3% of 15-75 year olds according to whether we consider only individuals not previously tested for any of the three viruses, or also those already tested for one or two of the viruses. Conclusions Our data are essential to guide decision-making regarding which new HCV screening recommendation to implement in France. They also highlight that efforts are still needed to achieve the WHO’s targets for eliminating these diseases. Home blood self-sampling may prove to be a useful tool for screening and epidemiological studies.http://link.springer.com/article/10.1186/s12879-019-4493-2Hepatitis CHepatitis BPrevalenceScreeningFrance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cécile Brouard Leïla Saboni Arnaud Gautier Stéphane Chevaliez Delphine Rahib Jean-Baptiste Richard Francis Barin Christine Larsen Cécile Sommen Josiane Pillonel Elisabeth Delarocque-Astagneau Nathalie Lydié Florence Lot the 2016 Health Barometer Group |
spellingShingle |
Cécile Brouard Leïla Saboni Arnaud Gautier Stéphane Chevaliez Delphine Rahib Jean-Baptiste Richard Francis Barin Christine Larsen Cécile Sommen Josiane Pillonel Elisabeth Delarocque-Astagneau Nathalie Lydié Florence Lot the 2016 Health Barometer Group HCV and HBV prevalence based on home blood self-sampling and screening history in the general population in 2016: contribution to the new French screening strategy BMC Infectious Diseases Hepatitis C Hepatitis B Prevalence Screening France |
author_facet |
Cécile Brouard Leïla Saboni Arnaud Gautier Stéphane Chevaliez Delphine Rahib Jean-Baptiste Richard Francis Barin Christine Larsen Cécile Sommen Josiane Pillonel Elisabeth Delarocque-Astagneau Nathalie Lydié Florence Lot the 2016 Health Barometer Group |
author_sort |
Cécile Brouard |
title |
HCV and HBV prevalence based on home blood self-sampling and screening history in the general population in 2016: contribution to the new French screening strategy |
title_short |
HCV and HBV prevalence based on home blood self-sampling and screening history in the general population in 2016: contribution to the new French screening strategy |
title_full |
HCV and HBV prevalence based on home blood self-sampling and screening history in the general population in 2016: contribution to the new French screening strategy |
title_fullStr |
HCV and HBV prevalence based on home blood self-sampling and screening history in the general population in 2016: contribution to the new French screening strategy |
title_full_unstemmed |
HCV and HBV prevalence based on home blood self-sampling and screening history in the general population in 2016: contribution to the new French screening strategy |
title_sort |
hcv and hbv prevalence based on home blood self-sampling and screening history in the general population in 2016: contribution to the new french screening strategy |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2019-10-01 |
description |
Abstract Background The advent of effective direct-acting antivirals (DAAs), has prompted an assessment of the French Hepatitis C virus (HCV) screening strategy, which historically targeted high-risk groups. One of the options put forward is the implementation of combined (i.e., simultaneous) HCV, Hepatitis B virus (HBV) and HIV screening for all adults at least once during their lifetime (“universal combined screening”). However, recent national survey-based data are lacking to guide decision-making regarding which new strategy to implement. Accordingly, we aimed to provide updated data for both chronic hepatitis C (CHC) and B (CHB) prevalence and for HCV and HBV screening history, using data from the BaroTest and 2016 Health Barometer (2016-HB) studies, respectively. Methods 2016-HB was a national cross-sectional phone based health survey conducted in 2016 among 20,032 randomly selected individuals from the general population in mainland France. BaroTest was a virological sub-study nested in 2016-HB. Data collected for BaroTest were based on home blood self-sampling on dried blood spots (DBS). Results From 6945 analyzed DBS, chronic hepatitis C (CHC) and B (CHB) prevalence was estimated at 0.30% (95% Confidence Interval (CI): 0.13-0.70) and 0.30% (95% CI: 0.13-0.70), respectively. The proportion of individuals aware of their status was estimated at 80.6% (95% CI: 44.2-95.6) for CHC and 17.5% (95% CI: 4.9-46.4) for CHB. Universal combined screening would involve testing between 32.6 and 85.3% of 15-75 year olds according to whether we consider only individuals not previously tested for any of the three viruses, or also those already tested for one or two of the viruses. Conclusions Our data are essential to guide decision-making regarding which new HCV screening recommendation to implement in France. They also highlight that efforts are still needed to achieve the WHO’s targets for eliminating these diseases. Home blood self-sampling may prove to be a useful tool for screening and epidemiological studies. |
topic |
Hepatitis C Hepatitis B Prevalence Screening France |
url |
http://link.springer.com/article/10.1186/s12879-019-4493-2 |
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