An Acute Brucellosis Case Presented with Pancytopenia and Hepatitis

• Main Authors: Heval Bilek, Ümit Alanbayı, Tayibe Bal
• Format: Article
• Language: English
• Published: Dicle University Medical School 2018-03-01
• Series: Dicle Medical Journal
• Subjects: Brucellosis; pancytopenia
• Online Access: http://www.diclemedj.org/upload/sayi/68/Dicle%20Med%20J-03302.pdf

Brucellosis is a common zoonotic disease in endemic areas like Turkey. It is an infection that can be manifested by extensive clinical findings, for this reason it can be difficult to diagnose. In humans, treatment of the disease requires long-lasting combined antibiotics and appropriate treatment regimens, but it is often difficult to achieve this success in countries with limited resources. Therefore, this may be an important economic burden in terms of both cost of treatment and potential loss of labor in individuals affected by brucellosis. A 23-year-old male patient who was presented with fever, pancytopenia and hepatitis, was hospitalized with the aim of investigating the etiology of fever. On laboratory findings supporting the Brusella disease, we started treatment with the combination of gentamycin and doxycycline to avoid drug-induced hepatotoxic effect. Laboratory findings were successfully improved while clinical complaints decreased. Brucella disease should be kept in mind in in endemic areas, concerning patients with abnormal laboratory findings of the hematopoietic or hepatobiliary system. Taking into consideration the side effects of the medicines used in the treatment of the disease, effective and least toxic combinations should be selected.